STK39 Antikörper (Middle Region)

Produktnummer ABIN360385

Produktdetails anti-STK39 Antikörper

Target: STK39 (serine threonine Kinase 39 (STK39))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STK39 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to SPAK.

Aufreinigung: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human SPAK.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu STK39

Target: STK39 (serine threonine Kinase 39 (STK39))

Andere Bezeichnung: STK39 / SPAK (STK39 Produkte)

Synonyme: dcht antikoerper, pask antikoerper, spak antikoerper, MGC69537 antikoerper, DCHT antikoerper, PASK antikoerper, SPAK antikoerper, Spak antikoerper, AW227544 antikoerper, AW556857 antikoerper, RF005 antikoerper, Rnl5 antikoerper, serine/threonine kinase 39 antikoerper, serine/threonine kinase 39 L homeolog antikoerper, serine threonine kinase 39 antikoerper, stk39 antikoerper, STK39 antikoerper, stk39.L antikoerper, Stk39 antikoerper

Hintergrund: SPAK is a serine/threonine kinase containing an N-terminal series of proline and alanine repeats (PAPA box), followed by a serine/threonine kinase catalytic domain, a nuclear localization signal, a consensus caspase cleavage recognition motif, and a C-terminal region. Northern blot analysis detects ubiquitous expression, most abundantly in brain and pancreas. SPAK can phosphorylate itself and an exogenous substrate in vitro. SPAK immunoprecipitates from transfected mammalian cells in a complex with another serine/threonine kinase that phosphorylates catalytically inactive SPAK. SPAK activates the p38 MAP kinase pathway in cotransfection assays. Full-length SPAK is expressed in the cytoplasm in transfected cells, while a mutant corresponding to caspase-cleaved STK39 localizes predominantly in the nucleus.Synonyms: DCHT, STE20/SPS1-related proline-alanine-rich protein kinase, Serine/threonine-protein kinase 39, Ste-20-related kinase

Gen-ID: 27347, 9606

UniProt: Q9UEW8