RAF1 Antikörper (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1) (N-Term)

Details for Product anti-RAF1 Antibody No. ABIN360145, Anbieter: Anmelden zum Anzeigen
Antigen
  • c-raf
  • craf
  • raf1
  • RAF1
  • raf
  • CRAF
  • NS5
  • Raf-1
  • c-Raf
  • 6430402F14Rik
  • AA990557
  • BB129353
  • Craf1
  • D830050J10Rik
  • v-Raf
  • AFR1
  • RAF
  • Afr-1
  • Afr1
  • Raf
  • mKIAA0854
  • v-raf-1 murine leukemia viral oncogene homolog 1a
  • v-raf-1 murine leukemia viral oncogene homolog 1
  • raf protein
  • v-raf-leukemia viral oncogene 1
  • zinc fingers and homeoboxes 2
  • raf1a
  • RAF1
  • raf1
  • LOC100341921
  • LOC100347407
  • c-raf
  • Raf1
  • ZHX2
  • Zhx2
Alternativen
anti-Human RAF1 Antikörper für Cytometry by Time of Flight
Epitop
N-Term
73
72
46
40
39
37
28
28
28
27
22
22
22
20
19
18
17
15
15
15
15
15
14
14
10
8
8
7
6
6
6
6
6
4
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
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Reaktivität
Human
808
411
386
25
23
16
16
13
8
8
8
5
4
4
2
2
1
1
1
Wirt
Kaninchen
769
46
12
6
2
Klonalität
Polyklonal
Konjugat
Dieser RAF1 Antikörper ist unkonjugiert
44
44
43
29
29
29
13
13
12
12
12
12
12
12
12
12
12
1
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
489
348
202
172
156
103
50
34
19
17
17
7
2
2
2
1
Optionen
Hersteller
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human RAF1.
Isotyp Ig
Spezifität This antibody reacts to RAF1.
Reinigung Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Andere Bezeichnung RAF1 (RAF1 Antibody Abstract)
Hintergrund RAF1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, RAF1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.Synonyms: C-RAF, RAF proto-oncogene serine/threonine-protein kinase, Raf-1, cRaf
Gen-ID 5894, 9606
UniProt P04049
Forschungsgebiet Signaling, Kinases/Phosphatases
Pathways MAPK Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, cAMP Metabolic Process, Stem Cell Maintenance, Hepatitis C, Autophagie, Signaling of Hepatocyte Growth Factor Receptor
Applikationshinweise ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Bilder des Herstellers
 image for anti-RAF1 Antikörper (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1) (N-Term) (ABIN360145) anti-V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) (N-Term) antibody
 image for anti-RAF1 Antikörper (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1) (N-Term) (ABIN360145) anti-V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) (N-Term) antibody (Image 2)
Allgemeine Veröffentlichungen Chong, Guan: "Regulation of Raf through phosphorylation and N terminus-C terminus interaction." in: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36269-76, 2003 (PubMed).

Lee, Koh, Han: "Down-regulation of Raf-1 kinase is associated with paclitaxel resistance in human breast cancer MCF-7/Adr cells." in: Cancer letters, Vol. 193, Issue 1, pp. 57-64, 2003 (PubMed).