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PHLPP2 Antikörper (N-Term)

PHLPP2 Reaktivität: Human IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN360110
  • Target Alle PHLPP2 Antikörper anzeigen
    PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
    Bindungsspezifität
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 16
    • 5
    • 2
    • 1
    • 1
    Human
    Wirt
    • 15
    • 1
    Kaninchen
    Klonalität
    • 16
    Polyklonal
    Konjugat
    • 16
    Dieser PHLPP2 Antikörper ist unkonjugiert
    Applikation
    • 16
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody reacts to PHLPP2.
    Aufreinigung
    Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human PHLPP2.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product PHLPP2 Primärantikörper
  • Applikationshinweise
    ELISA: 1/1,000. Immunohistochemistry: 1/10 - 1/50.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    PHLPP2 (PH Domain and Leucine Rich Repeat Protein Phosphatase 2 (PHLPP2))
    Andere Bezeichnung
    PHLPP2 (PHLPP2 Produkte)
    Synonyme
    PHLPPL antikoerper, phlppl antikoerper, AI481772 antikoerper, C130044A18Rik antikoerper, Phlppl antikoerper, RGD1562857 antikoerper, PH domain and leucine rich repeat protein phosphatase 2 antikoerper, PH domain and leucine rich repeat protein phosphatase 2 S homeolog antikoerper, PHLPP2 antikoerper, phlpp2.S antikoerper, phlpp2 antikoerper, Phlpp2 antikoerper
    Hintergrund
    PHLPP2 is a protein phosphatase that specifically mediates dephosphorylation of 'Ser-473' of AKT1. This protein regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decrease cell proliferation. It also controls the phosphorylation of AKT3.Synonyms: KIAA0931, PH domain leucine-rich repeat-containing protein phosphatase 2, PH domain leucine-rich repeat-containing protein phosphatase-like, PHLPP-like, PHLPPL
    Gen-ID
    23035, 9606
    UniProt
    Q6ZVD8
    Pathways
    PI3K-Akt Signalweg, Fc-epsilon Rezeptor Signalübertragung
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