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DOK2 Antikörper (C-Term)

DOK2 Reaktivität: Human WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN359960
  • Target Alle DOK2 Antikörper anzeigen
    DOK2
    Bindungsspezifität
    • 22
    • 22
    • 15
    • 9
    • 9
    • 7
    • 7
    • 6
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 115
    • 78
    • 18
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    Human
    Wirt
    • 129
    • 1
    Kaninchen
    Klonalität
    • 129
    • 1
    Polyklonal
    Konjugat
    • 39
    • 10
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    Dieser DOK2 Antikörper ist unkonjugiert
    Applikation
    • 103
    • 52
    • 52
    • 45
    • 31
    • 19
    • 12
    • 11
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody reacts to DOK2.
    Aufreinigung
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human DOK2.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product DOK2 Primärantikörper
  • Applikationshinweise
    ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    DOK2
    Andere Bezeichnung
    DOK2 / p56 Dok2 (DOK2 Produkte)
    Synonyme
    DokR antikoerper, Frip antikoerper, Dok-2 antikoerper, p56DOK antikoerper, p56dok-2 antikoerper, docking protein 2 antikoerper, DOK2 antikoerper, Dok2 antikoerper
    Hintergrund
    Docking proteins interact with receptor tyrosine kinases and mediate particular biological responses using signal transduction. Dok-2 acts as a multiple docking protein downstream of receptor or non-receptor tyrosine kinases. By this mechanism it acts to negatively regulate signal transduction and cell proliferation controlled by cytokines in a feedback loop. Dok-2 is highly expressed in cells and tissues of hematopoietic origin as well as in lung. Expression of bcr/abl induces additional tyrosine phosphorylation of the Dok1 and Dok2 proteins and their association with Ras-GAP. Thus, it is suspected that DOK association regulates GAP activity toward Ras and that the Dok proteins serve as mediators of bcr-abl signaling. The role of Dok proteins in bcr-abl regulation may also be implicated in chronic myelogenous leukemia (CML), which is characterized by a Philadelphia chromosome translocation t(9,22). Such a mutation would result in a p210-bcr/abl chimeric protein-tyrosine kinase which has been found in many CML cases.Synonyms: Docking protein 2, Downstream of tyrosine kinase 2, p56(dok-2), p56Dok-2
    Gen-ID
    9046, 9606
    UniProt
    O60496
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