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Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2) (N-Term) Antikörper

Antigen

Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2)
Synonyme ACEH, DKFZp434A014, 2010305L05Rik, ACE2, zgc:92514, MGC127593, DKFZp469K2021, Ace2
Epitope
Alternativen

N-Term
Klonalität Polyklonal
Wirt
Alternativen

Kaninchen
Reaktivität
Alternativen

Human
Applikation
Alternativen Enzyme Immunoassay (EIA), Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)
Produktnummer ABIN358579
Menge 0.1 mg  (0.25 mg/ml)
Preis 330,00 €   Zzgl. Versandkosten €20,00 und MWSt
Lieferung nach
Verfügbarkeit Lieferung in 7 bis 10 Werktagen

Produktbeschreibung
Anwendungen Alternativen Sekundärantikörper zurück nach oben

Produktmerkmale Synonyms: Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, Angiotensin-convertingenzyme homolog
Weitere Bezeichnung ACE2
Gen-ID 59272
Swiss-Prot Q9BYF1
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated syntheticpeptide selected from the N-terminal region of human ACE2.
Kreuzreaktivität Human
Isotyp Ig  (Passende Sekundärantikörper)
Beschreibung ACE2 cDNA encodes a deduced 805-amino acid protein containing a potential 17-aminoacid N-terminal signal peptide and a putative 22-amino acid C-terminal membrane anchor. It also possesses a zinc metalloprotease consensus sequence and a conserved glutamineresidue that may function as a third zinc ligand. ACE2 is expressed predominantly invascular endothelial cells of the heart and kidney. ACE converts angiotensin I toangiotensin II, ACE2 converts angiotensin I to angiotensin 1-9, which has 9 amino acids. Angiotensin II is a potent blood vessel constrictor, while angiotensin 1-9 does not impactblood vessels but is cleaved by ACE to a shorter peptide, angiotensin 1-7, which is a bloodvessel dilator. Spike (S) proteins of coronaviruses, including the SARS coronavirus, bindwith cellular receptors to mediate infection of target cells. ACE2 binds the S1 domain of theSARS coronavirus S protein. SARS coronavirus replicates efficiently on ACE2-transfectedbut not mock-transfected 293T cells. Anti-ACE2 but not anti-ACE1 antibody blocks viralreplication on Vero E6 cells. It has been proposed that ACE2 is a functional receptor forSARS coronavirus.
Spezifität This antibody reacts to ACE2 (SARS Receptor). Species: Human. Others not tested.

Anwendungen
Alternativen Sekundärantikörper zurück nach oben

Applikationshinweise ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Immunohistochemistry: 1/10 - 1/50. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Konzentration 0.25 mg/ml
Reinigung Purified
Buffer PBS with 0.09% (W/V) sodium azide
Lagerung Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Forschungsgebiet Metabolismus, Enzyme, Serum/Plasma Proteine
Beschränkungen Nur für Forschungszwecke einsetzbar

Alternativen
Anwendungen Sekundärantikörper zurück nach oben

Alternativen zu Antigen "Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2 (ACE2)", Typ "Antikörper" finden
Wirte Kaninchen (64), Maus (1)
Reaktivitäten Human (64), Maus (26), Ratte (Rattus) (21), Hund (17), Schwein (16), Schaf (15), Rind (Kuh) (2), Pferd (1)
Applikationen Western Blot (WB) (45), Immunhistochemie (Paraffinschnitte) (IHC (p)) (22), Durchflusszytometrie (FACS) (20), Immunfluoreszenz (IF) (18), ELISA (13), Enzyme Immunoassay (EIA) (12), Immunhistochemie (IHC) (8), Immunpräzipitation (IP) (3), Dot Blot (Dot) (2), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (2), Immunoelectron Microscopy (IEM) (1)
Konjugate Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
Epitope C-Term (3), N-Term (3), Center (2), Middle (1), N-Term K187 (1)