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MAP4K1 Antikörper (pSer171)

MAP4K1 Reaktivität: Human EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN358386
  • Target Alle MAP4K1 Antikörper anzeigen
    MAP4K1 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1))
    Bindungsspezifität
    • 16
    • 10
    • 8
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer171
    Reaktivität
    • 61
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 56
    • 4
    • 1
    Kaninchen
    Klonalität
    • 58
    • 3
    Polyklonal
    Konjugat
    • 31
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAP4K1 Antikörper ist unkonjugiert
    Applikation
    • 51
    • 33
    • 15
    • 14
    • 14
    • 14
    • 8
    • 8
    • 4
    • 4
    • 2
    • 1
    • 1
    Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects MAP4K1 pSer171. Predicted to cross react with Mouse (100 % Antigen Homology).
    Aufreinigung
    Affinity purification in a 2-step procedure with the control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S171 of human MAP4K1.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product MAP4K1 Primärantikörper
  • Applikationshinweise
    ELISA: 1/1,000. Dot Blot: 1/500.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) Sodium Azide as preservative.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    MAP4K1 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 (MAP4K1))
    Andere Bezeichnung
    MAP4K1 (MAP4K1 Produkte)
    Synonyme
    HPK1 antikoerper, Hpk1 antikoerper, mHPK1 antikoerper, mitogen activated protein kinase kinase kinase kinase 1 antikoerper, mitogen-activated protein kinase kinase kinase kinase 1 antikoerper, Map4k1 antikoerper, MAP4K1 antikoerper
    Hintergrund
    The c-Jun amino-terminal kinases (JNKs)/stress-activated protein kinases (SAPKs) play a crucial role in stress responses in mammalian cells. The mechanism underlying this pathway in the hematopoietic system is unclear, but it is a key in understanding the molecular basis of blood cell differentiation. We have cloned a novel protein kinase, termed hematopoietic progenitor kinase 1 (HPK1), that is expressed predominantly in hematopoietic cells, including early progenitor cells. HPK1 is related distantly to the p21(Cdc42/Rac1)-activated kinase (PAK) and yeast STE20 implicated in the mitogen-activated protein kinase (MAPK) cascade. Expression of HPK1 activates JNK1 specifically, and it elevates strongly AP-1-mediated transcriptional activity in vivo. HPK1 binds and phosphorylates MEKK1 directly, whereas JNK1 activation by HPK1 is inhibited by a dominant-negative MEKK1 or MKK4/SEK mutant. Interestingly, unlike PAK65, HPK1 does not contain the small GTPase Rac1/Cdc42-binding domain and does not bind to either Rac1 or Cdc42, suggesting that HPK1. activation is Rac1/Cdc42-independent. These results indicate that HPK1 is a novel functional activator of the JNK/SAPK signaling pathway.Synonyms: HPK1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEKKK 1, Mitogen-activated protein kinase kinase kinase kinase 1
    Molekulargewicht
    91166 Da
    Gen-ID
    11184, 9606
    UniProt
    Q92918
    Pathways
    T-Zell Rezeptor Signalweg, Signaling of Hepatocyte Growth Factor Receptor
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