HGS Antikörper (N-Term)

Produktnummer ABIN357582

Produktdetails anti-HGS Antikörper

Target: HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HGS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody is specific to HGS (N-term).

Aufreinigung: Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human HGS.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western Blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu HGS

Target: HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))

Andere Bezeichnung: HGS / HRS (HGS Produkte)

Synonyme: HRS antikoerper, Hrs antikoerper, fi34f05 antikoerper, zgc:63492 antikoerper, wu:fi34f05 antikoerper, Hgr antikoerper, ZFYVE8 antikoerper, CG2903 antikoerper, Dmel\\CG2903 antikoerper, HRS-2 antikoerper, Vps27 antikoerper, hrs antikoerper, l(2)23AB5 antikoerper, l(2)23Ad antikoerper, l(2)23Ad(Hrs) antikoerper, vps27 antikoerper, hgs antikoerper, hepatocyte growth factor-regulated tyrosine kinase substrate antikoerper, HGF-regulated tyrosine kinase substrate antikoerper, Hepatocyte growth factor regulated tyrosine kinase substrate antikoerper, hepatocyte growth factor-regulated tyrosine kinase substrate L homeolog antikoerper, HGS antikoerper, Hgs antikoerper, hgs antikoerper, Hrs antikoerper, hgs.L antikoerper

Hintergrund: HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. HGS may concentrate ubiquitinated receptors within clathrin-coated regions. It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.Synonyms: Hepatocyte growth factor-regulated tyrosine kinase substrate, Protein pp110

Molekulargewicht: 86192 Da

Gen-ID: 9146, 9606

UniProt: O14964

Pathways: EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Synaptic Vesicle Exocytosis, EGFR Downregulation