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SMURF1 Antikörper (N-Term)

SMURF1 Reaktivität: Human, Maus WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN357469
  • Target Alle SMURF1 Antikörper anzeigen
    SMURF1 (SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1))
    Bindungsspezifität
    • 8
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 57
    • 22
    • 3
    Human, Maus
    Wirt
    • 53
    • 4
    Kaninchen
    Klonalität
    • 54
    • 3
    Polyklonal
    Konjugat
    • 22
    • 7
    • 6
    • 6
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SMURF1 Antikörper ist unkonjugiert
    Applikation
    • 47
    • 39
    • 28
    • 10
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects SMURF1 at N-term.
    Aufreinigung
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human SMURF1.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product SMURF1 Primärantikörper
  • Applikationshinweise
    ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • Target
    SMURF1 (SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1))
    Andere Bezeichnung
    SMURF1 (SMURF1 Produkte)
    Synonyme
    4930431E10Rik antikoerper, mKIAA1625 antikoerper, RGD1309707 antikoerper, SMAD specific E3 ubiquitin protein ligase 1 antikoerper, E3 ubiquitin-protein ligase SMURF1 antikoerper, SMAD specific E3 ubiquitin protein ligase 1 L homeolog antikoerper, SMURF1 antikoerper, LOC100540915 antikoerper, smurf1 antikoerper, Smurf1 antikoerper, smurf1.L antikoerper
    Hintergrund
    Members of the transforming growth factor-beta (TGFB) family signal through type I and type II serine/threonine-kinase receptors, which in turn activate the SMAD signaling pathway. Bone morphogenetic protein (BMP) receptors target SMAD1, SMAD5, and SMAD8, whereas receptors for activin and TGFB (e.g., ACVR1 and TGFBR1, respectively) target SMAD2 and SMAD3. Phosphorylation of these receptor-regulated SMADs induces their association with the common-partner SMAD, SMAD4. Smurf1, a HECT domain E3 ubiquitin ligase, regulates cell polarity and protrusive activity and is required to maintain the transformed morphology and motility of a tumor cell. Atypical protein kinase C-zeta (PKC2), an effector of the Cdc42/Rac1-PAR6 polarity complex, recruits Smurf1 to cellular protrusions, where it controlled the local level of RhoA. Smurf1 thus links the polarity complex to degradation of RhoA in lamellipodia and filopodia to prevent RhoA signaling during dynamic membrane movements.Synonyms: E3 ubiquitin-protein ligase SMURF1, KIAA1625, SMAD ubiquitination regulatory factor 1, SMAD-specific E3 ubiquitin-protein ligase 1, SMURF 1, SMURF-1
    Molekulargewicht
    86113 Da
    Gen-ID
    57154, 9606
    UniProt
    Q9HCE7
    Pathways
    Regulation of Cell Size
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