Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

DKK4 Antikörper (N-Term)

DKK4 Reaktivität: Human WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN357073
  • Target Alle DKK4 Antikörper anzeigen
    DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))
    Bindungsspezifität
    • 18
    • 8
    • 8
    • 7
    • 6
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 7-36, N-Term
    Reaktivität
    • 61
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 63
    • 3
    • 1
    Kaninchen
    Klonalität
    • 65
    • 2
    Polyklonal
    Konjugat
    • 25
    • 10
    • 8
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DKK4 Antikörper ist unkonjugiert
    Applikation
    • 59
    • 42
    • 33
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Sequenz
    DKK4
    Spezifität
    This antibody detects DKK4 at N-term.
    Aufreinigung
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogen
    KLH conjugated synthetic peptide between 7~36 amino acids from the N-terminal region of Human DKK4
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product DKK4 Primärantikörper
  • Applikationshinweise
    ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    DKK4 (Dickkopf Homolog 4 (Xenopus Laevis) (DKK4))
    Andere Bezeichnung
    Dickkopf-4 (DKK4) (DKK4 Produkte)
    Synonyme
    DKK-4 antikoerper, Dkk-4 antikoerper, RGD1563172 antikoerper, dickkopf WNT signaling pathway inhibitor 4 antikoerper, DKK4 antikoerper, Dkk4 antikoerper
    Hintergrund
    DKK4, like DKK1, DKK2, and DKK3, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cysteine residues each. The second cysteine region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis detected no expression of DKK4, but RT-PCR analysis detected DKK4 expression in cerebellum, T-cell, esophagus, and lung cDNA libraries. DKK4 blocks Xenopus Wnt8, Wnt3a, and Wnt2b, but not Dsh or Fz8, induction of a secondary axis in frog embryos, indicating that DKKs antagonize WNT function upstream of WNT receptors.Synonyms: Dickkopf-related protein 4, Dkk-4
    Molekulargewicht
    24875 Da
    Gen-ID
    27121, 9606
    UniProt
    Q9UBT3
    Pathways
    WNT Signalweg
Sie sind hier:
Kundenservice