Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4) (1st cytoplasmic loop) Antikörper

Antigen: Transient Receptor Potential Cation Channel, Subfamily V, Member 4 (TRPV4)

Synonyme: VRL2, TRP12, VRL-2, VROAC, OTRPC4, VR-OAC, TRPV4, wu:fp52e02, Trp12, MGC150050, 0610033B08Rik, Vroac, Otrpc4

Epitope: 1st cytoplasmic loop

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN351286

Produktbeschreibung

Weitere Bezeichnung: TRPV4 (VRL-2, VRL2) (1t cytoplasmic loopl)

Swiss-Prot: Q9HBA0

Immunogen: A synthetic peptide afrom the 1t cytoplasmic loop of human TRPV4 (VRL-2) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Beschreibung: This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. FUNCTION: Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Note: Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. Also known as: Transient receptor potential cation channel subfamily V member 4, TrpV4, osm-9-like TRP channel 4, OTRPC4, vanilloid receptor-like channel 2, vanilloid receptor-like protein 2, VRL-2, vanilloid receptor-related osmotically-activated channel, VR-OAC, transient receptor potential protein 12, TRP12, VRL2, TRP12, VROAC.

Spezifität: Appears to be specific for TRPV4.

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Strotmann, Harteneck, Nunnenmacher et al.: "OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity." in: Nature cell biology, Vol. 2, Issue 10, pp. 695-702, 2000 (PubMed).

Liedtke, Choe, Martui-Renom et al.: "Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor." in: Cell, Vol. 103, Issue 3, pp. 525-35, 2000 (PubMed).

Suzuki, Mizuno, Kodaira et al.: "Impaired pressure sensation in mice lacking TRPV4." in: The Journal of biological chemistry, Vol. 278, Issue 25, pp. 22664-8, 2003 (PubMed).

Strotmann, Schultz, Plant: "Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site." in: The Journal of biological chemistry, Vol. 278, Issue 29, pp. 26541-9, 2003 (PubMed).

Arniges, Fernuandez-Fernuandez, Albrecht et al.: "Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking." in: The Journal of biological chemistry, Vol. 281, Issue 3, pp. 1580-6, 2006 (PubMed).