Transient Receptor Potential Cation Channel, Subfamily V, Member 2 (TRPV2) (1st cytoplasmic loop) Antikörper

Antigen: Transient Receptor Potential Cation Channel, Subfamily V, Member 2 (TRPV2)

Synonyme: VRL, VRL1, VRL-1, MGC12549, GRC, Vrl1, OTRPC2, MGC105451, TRPV2

Epitope: 1st cytoplasmic loop

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN351262

Produktbeschreibung

Weitere Bezeichnung: TRPV2 (VRL, VRL1, VRL-1, OTRPC2) (1t cytoplasmic loopl)

Swiss-Prot: Q9Y5S1

Immunogen: A synthetic peptide from the 1t cytoplasmic loop of human TRPV2 (VRL, VRL1, VRL-1, OTRPC2) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Beschreibung: This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. FUNCTION: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. SUBUNIT: Homotetramer. Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with RGA. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasm. Melanosome. Note: Translocates from the cytoplasm to the plasma membrane upon ligand stimulation. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Also known as: Transient receptor potential cation channel subfamily V member 2, TrpV2, osm-9-like TRP channel 2, OTRPC2, vanilloid receptor-like protein, VRL, VRL1, VRL-1, OTRPC2, MGC12549.

Spezifität: Appears to be specific for TRPV3.

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Caterina, Rosen, Tominaga et al.: "A capsaicin-receptor homologue with a high threshold for noxious heat." in: Nature, Vol. 398, Issue 6726, pp. 436-41, 1999 (PubMed).

Smith, Gunthorpe, Kelsell et al.: "TRPV3 is a temperature-sensitive vanilloid receptor-like protein." in: Nature, Vol. 418, Issue 6894, pp. 186-90, 2002 (PubMed).

Voets, Prenen, Vriens et al.: "Molecular determinants of permeation through the cation channel TRPV4." in: The Journal of biological chemistry, Vol. 277, Issue 37, pp. 33704-10, 2002 (PubMed).

Clapham, Julius, Montell et al.: "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels." in: Pharmacological reviews, Vol. 57, Issue 4, pp. 427-50, 2005 (PubMed).

Penna, Juvin, Chemin et al.: "PI3-kinase promotes TRPV2 activity independently of channel translocation to the plasma membrane." in: Cell calcium, Vol. 39, Issue 6, pp. 495-507, 2006 (PubMed).

Saunders, Kunde, Crawford et al.: "Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood." in: Molecular immunology, Vol. 44, Issue 6, pp. 1429-35, 2006 (PubMed).