Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1) (1st cytoplasmic loop) Antikörper

Antigen: Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1)

Synonyme: VR1, DKFZp434K0220, Vr1, Vr1l1, VR.5'sv, VR-1, OTRPC1, TRPV1beta, TRPV1alpha, TRPV1, Trpv1

Epitope: 1st cytoplasmic loop

Klonalität: Polyklonal

Wirt: Kaninchen

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN351258

Produktbeschreibung

Weitere Bezeichnung: TRPV1 (VR1, capsaicin receptor, vanilloid receptor 1) (1t cytoplasmic loop)

Swiss-Prot: Q704Y3

Immunogen: A synthetic peptide from the 1t cytoplasmic loop of TRPV1 (VR1, capsaicin receptor, vanilloid receptor 1) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Beschreibung: FUNCTION: Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH Also known as: Transient receptor potential cation channel subfamily V member 1, TrpV1, osm-9-like TRP channel 1, OTRPC1, Vanilloid receptor 1, Vanilloid receptor type 1-like, Capsaicin receptor, transient receptor potential cation channel, subfamily V, member 1, Vr1, Vr1l1, VR.5'sv.

Spezifität: Appears to be specific for TRPV1.

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 200 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Hu, Gu, Wang et al.: "2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3." in: The Journal of biological chemistry, Vol. 279, Issue 34, pp. 35741-8, 2004 (PubMed).

Correll, Phelps, Anthes et al.: "Cloning and pharmacological characterization of mouse TRPV1." in: Neuroscience letters, Vol. 370, Issue 1, pp. 55-60, 2004 (PubMed).