Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1) (3rd extracellular loop) Antikörper

Antigen: Transient Receptor Potential Cation Channel, Subfamily V, Member 1 (TRPV1)

Synonyme: VR1, DKFZp434K0220, Vr1, Vr1l1, VR.5'sv, VR-1, OTRPC1, TRPV1beta, TRPV1alpha, TRPV1, Trpv1

Epitope: 3rd extracellular loop

Klonalität: Polyklonal

Wirt: Schaf

Reaktivität: Kaninchen

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN351241

Produktbeschreibung

Weitere Bezeichnung: TRPV1 (VR1, capsaicin receptor, vanilloid receptor 1) (3d extracellular loop)

Swiss-Prot: Q6RX08

Immunogen: A synthetic peptide from the 3d extracellular loop of rabbit TRPV1 (VR1, capsaicin receptor, vanilloid receptor 1) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Beschreibung: FUNCTION: Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH Also known as: Transient receptor potential cation channel subfamily V member 1, TrpV1, osm-9-like TRP channel 1, OTRPC1, Vanilloid receptor 1, Vanilloid receptor type 1-like, Capsaicin receptor, transient receptor potential cation channel, subfamily V, member 1, Vr1, Vr1l1, VR.5'sv.

Spezifität: Appears to be specific for TRPV1.

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Nilius, Vennekens, Prenen et al.: "The single pore residue Asp542 determines Ca2+ permeation and Mg2+ block of the epithelial Ca2+ channel." in: The Journal of biological chemistry, Vol. 276, Issue 2, pp. 1020-5, 2001 (PubMed).

Gavva, Klionsky, Qu et al.: "Molecular determinants of vanilloid sensitivity in TRPV1." in: The Journal of biological chemistry, Vol. 279, Issue 19, pp. 20283-95, 2004 (PubMed).