TRPM7 Antikörper (4th Cytoplasmic Loop)

Produktnummer ABIN351219

Produktdetails anti-TRPM7 Antikörper

Target: TRPM7 (Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7))

Bindungsspezifität: 4th Cytoplasmic Loop

Reaktivität: Human

Wirt: Schaf

Klonalität: Polyklonal

Konjugat: Dieser TRPM7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Specific for TRPM7.

Kreuzreaktivität: Human, Ratte

Kreuzreaktivität (Details): Other species not yet tested.

Aufreinigung: IgG

Immunogen: A synthetic peptide from the 4th cytoplasmic loop of human TRPM7 (LTRPC7) conjugated to an immunogenic carrier protein was used as the immunogen.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu TRPM7

Target: TRPM7 (Transient Receptor Potential Cation Channel, Subfamily M, Member 7 (TRPM7))

Andere Bezeichnung: TRPM7 (TRPM7 Produkte)

Synonyme: cb495 antikoerper, TRPM7 antikoerper, chak antikoerper, chak1 antikoerper, ltrpc7 antikoerper, trp-plik antikoerper, ALSPDC antikoerper, CHAK antikoerper, CHAK1 antikoerper, LTRPC7 antikoerper, TRP-PLIK antikoerper, 2310022G15Rik antikoerper, 4833414K03Rik antikoerper, 5033407O22Rik antikoerper, LTrpC-7 antikoerper, Ltpr7 antikoerper, Ltrpc7 antikoerper, TRPPLIK antikoerper, Chak antikoerper, Trp-plik antikoerper, transient receptor potential cation channel subfamily M member 7 antikoerper, transient receptor potential cation channel, subfamily M, member 7 antikoerper, TRPM7 antikoerper, trpm7 antikoerper, Trpm7 antikoerper

Hintergrund: TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants. FUNCTION: Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). CATALYTIC ACTIVITY: ATP + a protein: ADP + a phosphoprotein. COFACTOR: Binds 1 zinc ion per subunit. SUBUNIT: Homodimer. Forms heterodimers with TRPM6. SUBCELLULAR LOCATION: Membrane, Multi-pass membrane protein.,Mammalian TRPM,Transient receptor potential cation channel subfamily M member 7, long transient receptor potential channel 7, LTrpC7, channel-kinase 1, CHAK1, LTRPC7, CHAK, FLJ20117, FLJ25718, TRP-PLIK

UniProt: Q96QT4