Transient Receptor Potential Cation Channel, Subfamily M, Member 6 (TRPM6) (4th cytoplasmic loop) Antikörper

Antigen: Transient Receptor Potential Cation Channel, Subfamily M, Member 6 (TRPM6)

Synonyme: HSH, HMGX, HOMG, CHAK2, HOMG1, TRPM6/CHAK2, TRPM6

Epitope: 4th cytoplasmic loop

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Ratte (Rattus)

Applikation: Immunhistochemie (IHC)

Produktnummer: ABIN351209

Produktbeschreibung

Weitere Bezeichnung: TRPM6 (CHAK2) (4th cytoplasmic loop)

Swiss-Prot: XP_001078158.1

Immunogen: A synthetic peptide from the 4th cytoplasmic loop of rat TRPM6 (CHAK2, HSH, HMGX, HOMG, HOMG1) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Beschreibung: FUNCTION: Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Forms heterodimers with TRPM7. TRPM6 requires the presence of TRPM7 to be targeted to the cell membrane (in HEK 293 cells). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in H510 small cell lung carcinoma cells. Also known as: Transient receptor potential cation channel subfamily M member 6, channel kinase 2, melastatin-related TRP cation channel 6, CHAK2, HSH, HMGX, HOMG, HOMG1.

Spezifität: Appears to be specific for TRPM6.

Anwendungen

Applikationshinweise: IHC. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Nagase, Kikuno, Nakayama et al.: "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 7, Issue 4, pp. 273-81, 2000 (PubMed).

Grimm, Kraft, Sauerbruch et al.: "Molecular and functional characterization of the melastatin-related cation channel TRPM3." in: The Journal of biological chemistry, Vol. 278, Issue 24, pp. 21493-501, 2003 (PubMed).

Lee, Chen, Sun et al.: "Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3)." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20890-7, 2003 (PubMed).

Humphray, Oliver, Hunt et al.: "DNA sequence and analysis of human chromosome 9." in: Nature, Vol. 429, Issue 6990, pp. 369-74, 2004 (PubMed).