Transient Receptor Potential Cation Channel, Subfamily C, Member 1 (TRPC1) (4th cytoplasmic loop) Antikörper

Antigen: Transient Receptor Potential Cation Channel, Subfamily C, Member 1 (TRPC1)

Synonyme: TRP1, HTRP-1, MGC133334, MGC133335, Trp1, Mtrp1, Trrp1, TRPC1, trpc1

Epitope: 4th cytoplasmic loop

Klonalität: Polyklonal

Wirt: Kaninchen

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN351120

Produktbeschreibung

Weitere Bezeichnung: TRPC1 (4th cytoplasmic loop)

Swiss-Prot: Q9QX01

Immunogen: A synthetic peptide from the 4th cytoplasmic loop of human TRPC1 conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat, mouse, bovine, rabbit and chicken TRPC1.

Format: Lyophilized

Beschreibung: FUNCTION: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. SUBUNIT: Interacts with TRPC3. Interacts with ITPR3. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Seems to be ubiquitous. Also known as: Short transient receptor potential channel 1, TrpC1, TRP-1 protein, Trp1, Trrp1, Trpc1 transient receptor potential cation channel, subfamily C, member 1, Mtrp1, Trp-related protein 1.

Spezifität: Appears to be specific for TRPC1.

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Wes, Chevesich, Jeromin et al.: "TRPC1, a human homolog of a Drosophila store-operated channel." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 21, pp. 9652-6, 1995 (PubMed).

Zhu, Chu, Peyton et al.: "Molecular cloning of a widely expressed human homologue for the Drosophila trp gene." in: FEBS letters, Vol. 373, Issue 3, pp. 193-8, 1995 (PubMed).

Zitt, Zobel, Obukhov et al.: "Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion." in: Neuron, Vol. 16, Issue 6, pp. 1189-96, 1996 (PubMed).

Wang, OConnell, Dykeman et al.: "Cloning of Trp1beta isoform from rat brain: immunodetection and localization of the endogenous Trp1 protein." in: The American journal of physiology, Vol. 276, Issue 4 Pt 1, pp. C969-79, 1999 (PubMed).

Lockwich, Liu, Singh et al.: "Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains." in: The Journal of biological chemistry, Vol. 275, Issue 16, pp. 11934-42, 2000 (PubMed).