Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1) (1t cytoplasmic loop) Antikörper

Antigen: Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1)

Synonyme: ANKTM1, CT18073, TRPA, TRPA1, dANKTM1, dTRPA1, Dmel\CG5751, CG5751, Anktm1, trpa1, GLEAN_02449

Epitope: 1t cytoplasmic loop

Klonalität: Polyklonal

Wirt: Kaninchen

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN351113

Produktbeschreibung

Weitere Bezeichnung: C. eleganceTRPA1 (ANKTM1,TRPa-1) (1t cytoplasmic loopl)

Swiss-Prot: Q18297

Immunogen: A synthetic peptide from the 1t cytoplasmic loop of C. Elegance TRPA1 (ANKTM1, trpa-1) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Beschreibung: FUNCTION: Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in many sensory neurons, including OLQ and IL1 neurons. MISCELLANEOUS: Worms lacking trpa-1 exhibit specific defects in mechanosensory behaviors: abnormal head withdrawal reflex, defective reversal behavior in response to nose-touch and foraging behaviors. Also known as: Transient receptor potential cation channel subfamily A member 1, ankyrin-like withtransmembrane domains protein 1, transformation sensitive protein p120, ANKTM1, trpa-1.

Spezifität: Appears to be specific for TRPA1.

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: "Genome sequence of the nematode C. elegans: a platform for investigating biology." in: Science (New York, N.Y.), Vol. 282, Issue 5396, pp. 2012-8, 1998 (PubMed).

Kindt, Viswanath, Macpherson et al.: "Caenorhabditis elegans TRPA-1 functions in mechanosensation." in: Nature neuroscience, Vol. 10, Issue 5, pp. 568-77, 2007 (PubMed).