Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1) (4th cytoplasmic loop) Antikörper

Antigen: Transient Receptor Potential Cation Channel, Subfamily A, Member 1 (TRPA1)

Synonyme: ANKTM1, CT18073, TRPA, TRPA1, dANKTM1, dTRPA1, Dmel\CG5751, CG5751, Anktm1, trpa1, GLEAN_02449

Epitope: 4th cytoplasmic loop

Klonalität: Polyklonal

Wirt: Kaninchen

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN351100

Produktbeschreibung

Weitere Bezeichnung: TRPA1 (ANKTM1) (4th cytoplasmic loop)

Swiss-Prot: Q6RI86

Immunogen: A synthetic peptide from the 4th cytoplasmic loop of rat TRPA1 (ANKTM1) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in mouse.

Format: Lyophilized

Beschreibung: The structure of the protein encoded by this gene is highly related to both the protein ankyrin andtransmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. TISSUE SPECIFICITY: Expressed in inner ear. In inner ear, it is found in the distal half of stereocilia, along the length of the kinocilium and at high level in the pericuticular zone (at protein level). Specifically expressed in a subset of nociceptive neurons. Expressed in the same neurons that TRPV1. In contrast, it is not expressed in neurons expressing TRPM8. Expressed in the superior cervical ganglion. DEVELOPMENTAL STAGE: During utricle development, it is first expressed at E15 and E16 and peaks at E17. It drops at E18 but increases again at E19, possibly corresponding to a second wave of hair cells that are generated at E15. Inhibited by ruthenium red, a potent blocker of TRPV channels. Also known as: Transient receptor potential cation channel subfamily A member 1, ankyrin-like withtransmembrane domains protein 1, transformation sensitive protein p120, ANKTM1.

Spezifität: Appears to be specific for TRPA1.

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

WB on mouse brain lysate (reduced, denatured) using Rabbit antibody to 4th cytoplasmic loop of TRPA1 (ANKTM1): whole serum (ABIN351100) at 1 : 1000 dilution.

Publikationen

Publikationen: Story, Peier, Reeve et al.: "ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures." in: Cell, Vol. 112, Issue 6, pp. 819-29, 2003 (PubMed).

Jordt, Bautista, Chuang et al.: "Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1." in: Nature, Vol. 427, Issue 6971, pp. 260-5, 2004 (PubMed).