TRKB Antikörper (pTyr816)

Produktnummer ABIN351082

Produktdetails anti-TRKB Antikörper

Target: TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))

Bindungsspezifität: AA 730-821, pTyr816

Reaktivität: Ratte

Wirt: Schaf

Klonalität: Polyklonal

Konjugat: Dieser TRKB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Specific for TrkB.

Kreuzreaktivität: Human, Maus, Ratte

Kreuzreaktivität (Details): Other species not yet tested.

Aufreinigung: IgG

Immunogen: A synthetic peptide from AA 730-821 (including phospho Y816 site) of rat TrkB conjugated to ablue carrier protein was used as the antigen. The peptide is homologous in human and mouse.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. This antibody is also likely to recognise the unphosphorylated form.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu TRKB

Target: TRKB (NTRK2) (Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2))

Andere Bezeichnung: TrkB (NTRK2 Produkte)

Synonyme: trkb antikoerper, trkb-b antikoerper, xtrkb antikoerper, si:ch211-220b11.1 antikoerper, trkB2 antikoerper, NTRK2 antikoerper, ntrk2 antikoerper, gp145-trkb antikoerper, TRKB antikoerper, GP145-TrkB antikoerper, trk-B antikoerper, AI848316 antikoerper, C030027L06Rik antikoerper, Tkrb antikoerper, trkB antikoerper, RATTRKB1 antikoerper, TRKB1 antikoerper, Trk-B antikoerper, TrkB antikoerper, neurotrophic receptor tyrosine kinase 2 antikoerper, neurotrophic receptor tyrosine kinase 2 L homeolog antikoerper, neurotrophic tyrosine kinase, receptor, type 2b antikoerper, neurotrophic receptor tyrosine kinase 2 S homeolog antikoerper, neurotrophic tyrosine kinase, receptor, type 2 antikoerper, NTRK2 antikoerper, ntrk2.L antikoerper, ntrk2b antikoerper, ntrk2.S antikoerper, ntrk2 antikoerper, Ntrk2 antikoerper

Hintergrund: FUNCTION: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS. SUBCELLULAR LOCATION: Membrane, Single-pass type I membrane protein.,Neurotrophic Receptors,Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB/GP95-TrkB, Trk-B, BDNF/NT-3 growth factors receptor

UniProt: Q16620

Pathways: RTK Signalweg, Neurotrophin Signalübertragung, cAMP Metabolic Process, Skeletal Muscle Fiber Development, Feeding Behaviour, Dicarboxylic Acid Transport