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TRKA Antikörper (Extracellular Domain)

NTRK1 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN351063
  • Target Alle TRKA (NTRK1) Antikörper anzeigen
    TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
    Bindungsspezifität
    • 36
    • 26
    • 25
    • 19
    • 16
    • 15
    • 15
    • 10
    • 10
    • 9
    • 8
    • 8
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Extracellular Domain
    Reaktivität
    • 238
    • 151
    • 144
    • 15
    • 4
    • 4
    • 1
    • 1
    Human
    Wirt
    • 247
    • 15
    • 3
    • 2
    Kaninchen
    Klonalität
    • 239
    • 27
    • 1
    Polyklonal
    Konjugat
    • 101
    • 18
    • 15
    • 13
    • 11
    • 11
    • 11
    • 11
    • 11
    • 11
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TRKA Antikörper ist unkonjugiert
    Applikation
    • 184
    • 99
    • 79
    • 78
    • 50
    • 38
    • 30
    • 20
    • 19
    • 14
    • 8
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Spezifität
    Specific for TrkA.
    Kreuzreaktivität
    Human
    Kreuzreaktivität (Details)
    Other species not yet tested.
    Aufreinigung
    IgG
    Immunogen
    A synthetic peptide from the extracellular domain of human TrkA conjugated to blue carrier protein was used as the antigen.
    Isotyp
    IgG
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  • Applikationshinweise
    IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
    Handhabung
    Avoid freeze and thaw cycles.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Haltbarkeit
    12 months
  • Target
    TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
    Andere Bezeichnung
    TrkA (NTRK1 Produkte)
    Synonyme
    MTC antikoerper, TRK antikoerper, TRK1 antikoerper, TRKA antikoerper, Trk-A antikoerper, p140-TrkA antikoerper, CDHF12 antikoerper, CDHR16 antikoerper, HSCR1 antikoerper, MEN2A antikoerper, MEN2B antikoerper, MTC1 antikoerper, PTC antikoerper, RET-ELE1 antikoerper, RET51 antikoerper, Trk antikoerper, C80751 antikoerper, Tkr antikoerper, TrkA antikoerper, trk antikoerper, trka antikoerper, CTRKA antikoerper, trkA antikoerper, neurotrophic receptor tyrosine kinase 1 antikoerper, ret proto-oncogene antikoerper, neurotrophic tyrosine kinase, receptor, type 1 antikoerper, NTRK1 antikoerper, RET antikoerper, Ntrk1 antikoerper, ntrk1 antikoerper
    Hintergrund
    FUNCTION: Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 which bridges NTRK1 to NGFR. Interacts with NGFR and ARMS. Can form a ternary complex with NGFR and ARMS and this complex is affected by the expression levels of ARMS. An increase in ARMS expression leads to a decreased association of NGFR and NTRK1. SUBCELLULAR LOCATION: Cell membrane, Single-pass type I membrane protein. Note: Endocytosed to the endosomes upon treatment of cells with NGF. TISSUE SPECIFICITY: Isoform Trka-II is primarily expressed in neuronal cells, isoform Trka-I is found in non-neuronal tissues.,Neurotrophic Receptors,High affinity nerve growth factor receptor, NTRK1, p140-TrkA, Trk-A, Neurotrophic tyrosine kinase receptor type 1, Slow nerve growth factor receptor
    UniProt
    P04629
    Pathways
    RTK Signalweg, Neurotrophin Signalübertragung, cAMP Metabolic Process
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