Trans-Golgi Network Protein 2 (TGOLN2) (cytoplasmic) Antikörper

Antigen: Trans-Golgi Network Protein 2 (TGOLN2)

Synonyme: TGN38, TGN46, TGN48, TGN51, TTGN2, MGC14722, TGN41, Ttgn2, TGN38B, TGOLN2, DKFZp469D101

Epitope: cytoplasmic

Klonalität: Polyklonal

Wirt: Kaninchen

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN351004

Produktbeschreibung

Weitere Bezeichnung: TGN (Trans-Golgi network, TGN51, TGN46, TGN48, TGN38) (cytoplasmic region)

Swiss-Prot: Q62314

Immunogen: A synthetic peptide from the cytoplasmic part of mouse TGN38 conjugated to an immunogenic carrier protein was used as the immunogen. The peptide is homologous in rat, human (TGN46, TGN48, TGN51).

Format: Lyophilized

Beschreibung: FUNCTION: May be involved in regulating membrane traffic to and from trans-Golgi network. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note: Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes. TISSUE SPECIFICITY: Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells. MISCELLANEOUS: Not found in strains BALB/c, C57BL/6 and DBA/2. Also known as: Trans-Golgi network protein TGN51, TGN46, TGN48, TGN38 homolog, Trans-Golgi network integral membrane protein 2, TGOLN2.

Spezifität: Appears to be specific for TGN38 (or TGN46, TGN48, TGN51 in human).

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Kasai, Takahashi, Murakami et al.: "Strain-specific presence of two TGN38 isoforms and absence of TGN41 in mouse." in: The Journal of biological chemistry, Vol. 270, Issue 24, pp. 14471-6, 1995 (PubMed).

Wu, MacCoss, Mardones et al.: "Organellar proteomics reveals Golgi arginine dimethylation." in: Molecular biology of the cell, Vol. 15, Issue 6, pp. 2907-19, 2004 (PubMed).

Hillier, Graves, Fulton et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." in: Nature, Vol. 434, Issue 7034, pp. 724-31, 2005 (PubMed).

Dai, Jin, Sheng et al.: "Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." in: Journal of proteome research, Vol. 6, Issue 1, pp. 250-62, 2007 (PubMed).

Dephoure, Zhou, Villuen et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).