Taste Receptor, Type 2, Member 46 (TAS2R46) (TAS2R47 T2R47) Antikörper

Antigen: Taste Receptor, Type 2, Member 46 (TAS2R46)

Synonyme: T2R46, T2R54, MGC134865, TAS2R43

Epitope: TAS2R47 T2R47

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN350987

Produktbeschreibung

Weitere Bezeichnung: taste receptor, type 2, member 47 (TAS2R47, T2R47)

Swiss-Prot: P59541

Immunogen: A synthetic peptide as a part of human taste receptor, type 2, member 47 (TAS2R47, T2R47) conjugated to immunogenic carrier protein was used as the immunogen. The antibody generated using this antigen is expected to also recognise TAS2R43, TAS2R44 and TAS2R45.

Format: Lyophilized

Beschreibung: FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli. Useful Links <||a href="http://bioportal.weizmann.ac.il/HORDE/links.html"> The Humanolfactory Data Exploratorium: HORDE <||/a> <||a href="http://senselab.med.yale.edu/senselab/ordb/">olfactory Receptor Data Base: ORDB<||/a><||a href="http://www.enzim.hu/hmmtop1.1/server/submit.html"> <||/a> Also known as: Taste receptor type 2 member 47, TAS2R47.

Spezifität: Appears to be specific for TAS2R47 ( and also TAS2R43, TAS2R44 and TAS2R45. See the Immunogen)

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 300 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Montmayeur, Matsunami: "Receptors for bitter and sweet taste." in: Current opinion in neurobiology, Vol. 12, Issue 4, pp. 366-71, 2002 (PubMed).

Bufe, Hofmann, Krautwurst et al.: "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides." in: Nature genetics, Vol. 32, Issue 3, pp. 397-401, 2002 (PubMed).

Zhang, Hoon, Chandrashekar et al.: "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways." in: Cell, Vol. 112, Issue 3, pp. 293-301, 2003 (PubMed).

Fischer, Gilad, Man et al.: "Evolution of bitter taste receptors in humans and apes." in: Molecular biology and evolution, Vol. 22, Issue 3, pp. 432-6, 2005 (PubMed).