Taste Receptor, Type 1, Member 1 (TAS1R1) (1t extracellular domain) Antikörper

Antigen: Taste Receptor, Type 1, Member 1 (TAS1R1)

Synonyme: Gpr70, TR1, T1R1, GPR70, gm148, T1r1, TAS1R1

Epitope: 1t extracellular domain

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Maus

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN350952

Produktbeschreibung

Weitere Bezeichnung: taste receptor, type 1, member 1 (Tas1r1, TS1R1) (1t extracellular domain)

Swiss-Prot: Q99PG6

Immunogen: A synthetic peptide from 1t extracellular domain of mouse taste receptor, type 1, member 1 (Tas1r1, Gpr70, T1r1, Tr1) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Beschreibung: FUNCTION: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. SUBUNIT: Forms heterodimers with TAS1R3. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed strongly only in fungiform papillae.<||a href="http://www.enzim.hu/hmmtop1.1/server/submit.html"><||/a> Also known as: Taste receptor type 1 member 1, Tas1r1, Gpr70, T1r1, Tr1, TS1R1.

Spezifität: Appears to be specific for TAS1R1.

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Li, Inoue, Reed et al.: "High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 12, Issue 1, pp. 13-6, 2001 (PubMed).

Montmayeur, Liberles, Matsunami et al.: "A candidate taste receptor gene near a sweet taste locus." in: Nature neuroscience, Vol. 4, Issue 5, pp. 492-8, 2001 (PubMed).

Nelson, Hoon, Chandrashekar et al.: "Mammalian sweet taste receptors." in: Cell, Vol. 106, Issue 3, pp. 381-90, 2001 (PubMed).

Nelson, Chandrashekar, Hoon et al.: "An amino-acid taste receptor." in: Nature, Vol. 416, Issue 6877, pp. 199-202, 2002 (PubMed).

Ariyasu, Matsumoto, Kyono et al.: "Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose." in: In vitro cellular & developmental biology. Animal, Vol. 39, Issue 1-2, pp. 80-8, 2003 (PubMed).