Syntaxin 7 (STX7) (N-Term) Antikörper

Antigen: Syntaxin 7 (STX7)

Synonyme: Avl, Dm Syx7, DmSyx7, SYX7, Syx, DmelCG5081, CG5081, Syn7, AI315064, AI317144, AW107239, STX7, F27G20.2, SYNTAXIN 24, SYP24, Syntaxin-7, DKFZp459F1627

Epitope: N-Term

Klonalität: Polyklonal

Wirt: Kaninchen

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN350938

Produktbeschreibung

Weitere Bezeichnung: Syntaxin-7 (STX7, Syn7,Syntaxin 7) (n-terminal region)

Swiss-Prot: O70257

Immunogen: A synthetic peptide as a part of rat, mouse Syntaxin-7 (STX7, Syn7, Syntaxin 7) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Beschreibung: FUNCTION: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. SUBUNIT: Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Interacts with VPS33A. Found in a complex with VAMP8 and VTI1B in the liver. Part of the SNARE core complex containing VAMP8, STX8 and VTI1B. Interacts with VPS11, VPS16 and VPS18. SUBCELLULAR LOCATION: Early endosome membrane; Single-pass type IV membrane protein. Also known as: Syntaxin-7, STX7, Syn7.

Spezifität: Appears to be specific for Syntaxin-7.

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

IHC on rat spinal cord (dorsal horn) using Rabbit antibody to rat, mouse Syntaxin-7 (STX7, Syn7, Syntaxin 7): whole serum (ABIN350938) at 1 : 1000 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the immunostaining (not shown).

IHC on rat trigeminal nerve using Rabbit antibody to rat, mouse Syntaxin-7 (STX7, Syn7, Syntaxin 7): whole serum (ABIN350938) at 1 : 1000 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the immunostaining (not shown).

IHC on rat spinal cord (central canal) using Rabbit antibody to rat, mouse Syntaxin-7 (STX7, Syn7, Syntaxin 7): whole serum (ABIN350938) at 1 : 1000 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the immunostaining (not shown).

Publikationen

Publikationen: Wong, Xu, Zhang et al.: "Syntaxin 7, a novel syntaxin member associated with the early endosomal compartment." in: The Journal of biological chemistry, Vol. 273, Issue 1, pp. 375-80, 1998 (PubMed).

Antonin, Holroyd, Fasshauer et al.: "A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function." in: The EMBO journal, Vol. 19, Issue 23, pp. 6453-64, 2000 (PubMed).

Antonin, Fasshauer, Becker et al.: "Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs." in: Nature structural biology, Vol. 9, Issue 2, pp. 107-11, 2002 (PubMed).

Pryor, Mullock, Bright et al.: "Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events." in: EMBO reports, Vol. 5, Issue 6, pp. 590-5, 2004 (PubMed).

Ballif, Villuen, Beausoleil et al.: "Phosphoproteomic analysis of the developing mouse brain." in: Molecular & cellular proteomics : MCP, Vol. 3, Issue 11, pp. 1093-101, 2004 (PubMed).

Munton, Tweedie-Cullen, Livingstone-Zatchej et al.: "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." in: Molecular & cellular proteomics : MCP, Vol. 6, Issue 2, pp. 283-93, 2007 (PubMed).

Villuen, Beausoleil, Gerber et al.: "Large-scale phosphorylation analysis of mouse liver." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 5, pp. 1488-93, 2007 (PubMed).