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STAM 1, 2 Antikörper

Reaktivität: Human IHC, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN350878
  • Target
    STAM 1, 2
    Reaktivität
    Human
    Wirt
    • 1
    Kaninchen
    Klonalität
    • 1
    Polyklonal
    Konjugat
    • 1
    Unkonjugiert
    Applikation
    Immunohistochemistry (IHC), Western Blotting (WB)
    Spezifität
    Specific for STAM1 & 2.
    Kreuzreaktivität
    Human, Marmoset, Maus, Ratte
    Kreuzreaktivität (Details)
    Other species not yet tested.
    Aufreinigung
    IgG
    Immunogen
    A synthetic peptide from human STAM 1, 2 (STAM-1, STAM-2) conjugated to blue carrier protein was used as the antigen. The peptide is homologous in many species including rat, mouse, zebra fish and xenopus.
    Isotyp
    IgG
  • Applikationshinweise
    IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
    Handhabung
    Avoid freeze and thaw cycles.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Haltbarkeit
    12 months
  • Target
    STAM 1, 2
    Hintergrund
    STAM1: FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a role in endocytic trafficking as well as in T-cell development. SUBUNIT: Heterodimer. Composed of STAM1 and HGS/HRS. Also interacts directly with STAMBP/AMSH. TISSUE SPECIFICITY: Ubiquitously expressed. STAM2: FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. Probably acts via its association with ubiquitinated cargo proteins on the early endosome participates in their sorting for trafficking to the lysosome. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and c-myc induction. May also play a in T-cell development. SUBUNIT: Heterodimer or heterotrimer. At least composed of STAM2 and HGS/Hrs. EPS15 can be part of the complex. Interacts directly with STAMBP/AMSH, JAK2 and JAK3. Also interacts with ubiquitinated proteins and the deubiquitinating enzyme USP8/UBPY. Interacts directly with CBX5 via the PxVxL motif. Interacts with VPS37C. TISSUE SPECIFICITY: Ubiquitously expressed.,Signal Transduction,STAM1, STAM-1, STAM2, STAM-2, Signal transducing adapter molecule 1, Signal transducing adapter molecule 2, HBP, Hrs-binding protein
    UniProt
    Q92783
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