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Sortilin 1 Antikörper (N-Term)

SORT1 Reaktivität: Ratte WB, IHC Wirt: Schaf Polyclonal unconjugated
Produktnummer ABIN350870
  • Target Alle Sortilin 1 (SORT1) Antikörper anzeigen
    Sortilin 1 (SORT1)
    Bindungsspezifität
    • 16
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 42
    • 33
    • 28
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 43
    • 7
    • 1
    Schaf
    Klonalität
    • 44
    • 7
    Polyklonal
    Konjugat
    • 27
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Sortilin 1 Antikörper ist unkonjugiert
    Applikation
    • 40
    • 19
    • 17
    • 13
    • 13
    • 12
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Spezifität
    Specific for Sortilin.
    Kreuzreaktivität
    Maus, Ratte
    Kreuzreaktivität (Details)
    Other species not yet tested.
    Aufreinigung
    IgG
    Immunogen
    A synthetic peptide from the extracellular, N-terminal region of rat Sortilin (Neurotensin receptor 3, NTR3, Sort1) conjugated to an immunogenic carrier protein was used as the antigen. The antigen shares 95% identity mouse sequence.
    Isotyp
    IgG
    Top Product
    Discover our top product SORT1 Primärantikörper
  • Applikationshinweise
    IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
    Handhabung
    Avoid freeze and thaw cycles.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Sortilin 1 (SORT1)
    Andere Bezeichnung
    Sortilin (SORT1 Produkte)
    Synonyme
    SORT1 antikoerper, 19.m02079 antikoerper, gp95 antikoerper, ldlcq6 antikoerper, sortilin antikoerper, Gp95 antikoerper, LDLCQ6 antikoerper, NT3 antikoerper, 2900053A11Rik antikoerper, AI852375 antikoerper, Ntr3 antikoerper, Ntsr3 antikoerper, Nt3 antikoerper, Nts3 antikoerper, sort1 antikoerper, zgc:85953 antikoerper, sortilin 1 antikoerper, sortilin antikoerper, sortilin 1 S homeolog antikoerper, sortilin 1a antikoerper, SORT1 antikoerper, TP01_0016 antikoerper, BBOV_I002730 antikoerper, sort1.S antikoerper, Sort1 antikoerper, sort1a antikoerper
    Hintergrund
    FUNCTION: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. SUBUNIT: Interacts with the cytosolic adapter proteins GGA1 and GGA2. Interacts with numerous ligands including the receptor-associated protein LRPAP1/RAP and GM2A, LPL, PSAP and SLC2A4. Forms a complex with NGFR which binds specifically to the precursor form of NGFB (proNGFB). Interacts with the precursor form of BDNF (proBDNF). SUBCELLULAR LOCATION: Membrane, Single-pass type I membrane protein. Note: Localized to membranes of the endosomes, Golgi stack, lysosomes and nucleus. Localization to the plasma membrane in adipocytes is enhanced by insulin. Localized to the endoplasmic reticulum and the plasma membrane. Also found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. TISSUE SPECIFICITY: Highly expressed in fat, brain, and lung. Expressed in neuronal bodies and dendrites of the piriform cortex and hippocampus. Also expressed in the islands of Calleja, medial and lateral septal nuclei, amygdaloid nuclei, thalamic nuclei, the supraoptic nucleus, the substantia nigra, the Purkinje layer of the cerebellar cortex and the cranial motor nerve nuclei of the brainstem.,Neurogenesis,Neurotensin receptor 3, NTR3, Glycoprotein 110, Gp110, Nt3, Nts3
    UniProt
    O54861
    Pathways
    Neurotrophin Signalübertragung
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