Rhodopsin Antikörper (C-Term)

Produktnummer ABIN350798

Produktdetails anti-Rhodopsin Antikörper

Target: Rhodopsin (RHO)

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Rhodopsin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Specific for Rhodopsin.

Immunogen: A synthetic peptide from c-terminal region of human Rhodopsin (OPSD, Opsin-2) conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in mouse and rat.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: A concentration of 10-50 µg/ml is recommended.
The optimal concentration should be determined by the end user.
Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu Rhodopsin

Target: Rhodopsin (RHO)

Andere Bezeichnung: Rhodopsin (RHO Produkte)

Synonyme: CSNBAD1 antikoerper, OPN2 antikoerper, RP4 antikoerper, RH1 antikoerper, Rh antikoerper, fi06d11 antikoerper, wu:fi06d11 antikoerper, zfo2 antikoerper, zfrho antikoerper, Noerg1 antikoerper, Opn2 antikoerper, Ops antikoerper, opn2 antikoerper, rh1 antikoerper, rp4 antikoerper, xrho antikoerper, PIGRHO1 antikoerper, ops antikoerper, RDP1 antikoerper, RHO antikoerper, rhodopsin antikoerper, rhodopsin L homeolog antikoerper, RHO antikoerper, Rho antikoerper, rho antikoerper, rho.L antikoerper

Substanzklasse: Chemical

Hintergrund: Function: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal. BIOPHYSICOCHEMICAL PROPERTIES: Absorption: Abs(max)=495 nm,
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Rod shaped photoreceptor cells which mediates vision in dim light. PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. DISEASE: Defects in RHO are the cause of retinitis pigmentosa type 4 (RP4). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP4 inheritance is autosomal dominant. DISEASE: Defects in RHO are a cause of retinitis pigmentosa autosomal recessive (ARRP). DISEASE: Defects in RHO are a cause of autosomal dominant congenital stationary night blindness 1 (CSNBAD1), also known as rhodopsin-related congenital stationary night blindness. Congenital stationary night blindness is a nonprogressive retinal disorder characterized by impaired night vision and ocular symptoms such as myopia, hyperopia, nystagmus and reduced visual acuity. Also known as: Rhodopsin, opsin-2, RHO, OPN2, RP4, MGC138309, MGC138311.

Pathways: WNT Signalweg, Sensory Perception of Sound, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction