rho Family GTPase 1 (RND1) Antikörper

Antigen: rho Family GTPase 1 (RND1)

Synonyme: ARHS, RHO6, RHOS, FLJ42294, rho6, XRnd1, MGC68867, arhs, rno6, rnd1b, MGC194913, MGC194927

Klonalität: Polyklonal

Wirt: Kaninchen

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN350793

Produktbeschreibung

Weitere Bezeichnung: Rho related GTP binding protein Rho6 (RND1)

Swiss-Prot: Q92730

Immunogen: Synthetic peptides (dimer) from human Rho related GTP binding protein Rho6 (RND1) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Beschreibung: Function: Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm › cytoskeleton. Tissue specificity: Mostly expressed in brain and liver. Also known as: Rho family GTPase 1, RND1, RHO6.

Spezifität: Appears to be specific for RND1.

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Nobes, Lauritzen, Mattei et al.: "A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion." in: The Journal of cell biology, Vol. 141, Issue 1, pp. 187-97, 1998 (PubMed).

Vayssiuere, Zalcman, Mahue et al.: "Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family." in: FEBS letters, Vol. 467, Issue 1, pp. 91-6, 2000 (PubMed).

Aoki, Katoh, Mori et al.: "Rnd1, a novel rho family GTPase, induces the formation of neuritic processes in PC12 cells." in: Biochemical and biophysical research communications, Vol. 278, Issue 3, pp. 604-8, 2000 (PubMed).

Katoh, Harada, Mori et al.: "Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers." in: Molecular and cellular biology, Vol. 22, Issue 9, pp. 2952-64, 2002 (PubMed).

Oinuma, Katoh, Harada et al.: "Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells." in: The Journal of biological chemistry, Vol. 278, Issue 28, pp. 25671-7, 2003 (PubMed).