Transient Receptor Potential Channel Pyrexia (pyx) (1st cytoplasmic domain) Antikörper

Antigen: Transient Receptor Potential Channel Pyrexia (pyx)

Epitope: 1st cytoplasmic domain

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Fruchtfliege (Drosophila melanogaster)

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN350776

Produktbeschreibung

Weitere Bezeichnung: PYX (Transient receptor potential channel pyrexia) (1t cytoplasmic loopl)

Swiss-Prot: Q9W0T5

Immunogen: A synthetic peptide from 1t cytoplasmic loop of drosophila PYX (Transient receptor potential channel pyrexia) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Beschreibung: FUNCTION: Receptor-activated non-selective cation channel involved in protection or tolerance from high temperature stress. Activated by temperatures above 40 degrees Celsius. More permeable to K(+) than to Na(+). May act in stress protection allow flies to survive in natural environments. SUBUNIT: Homooligomer; between isoform A and isoform B. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in various peripheral nerves and the central nerves in embryos. In adults, it is expressed in sensory neurons lying beneath the bristles around eyes, neurons innervating the bristles on the back of thorax and neurons in maxillary palps, proboscis and antennae. Expressed in multidendritic neurons, which mediate temperature sensing, as well as non-multidendritic neurons in larval epidermis. Localizes ubiquitously throughout neurites. Also known as: Transient receptor potential channel pyrexia.

Spezifität: Appears to be specific for PYX.

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Adams, Celniker, Holt et al.: "The genome sequence of Drosophila melanogaster." in: Science (New York, N.Y.), Vol. 287, Issue 5461, pp. 2185-95, 2000 (PubMed).

Lee, Lee, Lee et al.: "Pyrexia is a new thermal transient receptor potential channel endowing tolerance to high temperatures in Drosophila melanogaster." in: Nature genetics, Vol. 37, Issue 3, pp. 305-10, 2005 (PubMed).