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Pyx (pyx) (AA 400-450) Antikörper

Details zu Produkt Nr. ABIN350776, Anbieter: Anmelden zum Anzeigen
Antigen
  • CG17142
  • CT33412
  • Dmel\\CG17142
  • Pyx
Epitop
AA 400-450
1
Reaktivität
Fruchtfliege (Drosophila melanogaster)
1
Wirt
Kaninchen
1
Klonalität
Polyklonal
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
1
1
1
1
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Immunogen A synthetic peptide from aa region 400-450 of drosophila PYX conjugated to blue carrier protein was used as the antigen.
Spezifität Specific for PYX.
Reinigung Whole serum
Andere Bezeichnung PYX
Hintergrund Function: Receptor-activated non-selective cation channel involved in protection or tolerance from high temperature stress. Activated by temperatures above 40 degrees Celsius. More permeable to K(+) than to Na(+). May act in stress protection allow flies to survive in natural environments.
Subunit: Homooligomer, between isoform A and isoform B.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Expressed in various peripheral nerves and the central nerves in embryos. In adults, it is expressed in sensory neurons lying beneath the bristles around eyes, neurons innervating the bristles on the back of thorax and neurons in maxillary palps, proboscis and antennae. Expressed in multidendritic neurons, which mediate temperature sensing, as well as non-multidendritic neurons in larval epidermis. Localizes ubiquitously throughout neurites. Also known as: Transient receptor potential channel pyrexia.
Applikationshinweise A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Not yet tested in other applications.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handhabung Avoid freeze and thaw cycles.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Haltbarkeit 12 months
Allgemeine Veröffentlichungen Lee, Lee, Lee et al.: "Pyrexia is a new thermal transient receptor potential channel endowing tolerance to high temperatures in Drosophila melanogaster." in: Nature genetics, Vol. 37, Issue 3, pp. 305-10, 2005 (PubMed).

Adams, Celniker, Holt et al.: "The genome sequence of Drosophila melanogaster." in: Science (New York, N.Y.), Vol. 287, Issue 5461, pp. 2185-95, 2000 (PubMed).