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LIM Domain Kinase 2 (LIMK2) (pSer291), (pSer293) Antikörper

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Synonyme xlimk2, zgc:91990, wu:fa97c09, wu:fk73e11, LIMK2, Limk2b, Link2, LIMK, 9430059K01, A930024P04Rik, C85310, Limk2a
Epitop
pSer291, pSer293
(28), (15), (10), (9), (7), (5), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität
Maus, Ratte (Rattus), Human
(129), (63), (60), (1)
Wirt
Schaf
(117), (7), (3), (2)
Klonalität
Polyklonal
Konjugat
Unkonjugiert
(1)
Applikation
Immunhistochemie (IHC), Western Blot (WB)
(111), (55), (44), (41), (16), (11), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 5 Publikationen vorhanden
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Menge 100 μL
Optionen
Lieferung nach Deutschland ( )
Verfügbarkeit Lieferung in 7 bis 8 Werktagen
Immunogen A synthetic peptide from the phospho S291 & S293 region of human LIMK2 (LIM domain kinase 2, LIMK-2) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat, mouse.
Spezifität Specific for LIMK2.
Reinigung Whole serum
Andere Bezeichnung LIMK2 (LIMK2 Antibody Abstract)
Hintergrund Function: Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Subcellular location: Cytoplasm. Nucleus. Note: Isoform LIMK2a is distributed in the cytoplasm and the nucleus, and isoform LIMK2b occurs mainly in the cytoplasm and is scarcely translocated to the nucleus.
Tissue specificity: Highest expression in the placenta, moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form. In adult lung, both LIMK2a and LIMK2b is nearly equally observed. Also known as: LIM domain kinase 2, LIMK-2.
Applikationshinweise A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user. This antibody may also recognise the unphosphorylated form.
Not yet tested in other applications.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handhabung Avoid freeze and thaw cycles.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Haltbarkeit 12 months
Allgemeine Veröffentlichungen Sumi, Matsumoto, Nakamura: "Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase." in: The Journal of biological chemistry, Vol. 276, Issue 1, pp. 670-6, 2001 (PubMed).

Dunham, Shimizu, Roe et al.: "The DNA sequence of human chromosome 22. ..." in: Nature, Vol. 402, Issue 6761, pp. 489-95, 1999 (PubMed).

Maekawa, Ishizaki, Boku et al.: "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase." in: Science (New York, N.Y.), Vol. 285, Issue 5429, pp. 895-8, 1999 (PubMed).

Osada, Hasada, Inazawa et al.: "Subcellular localization and protein interaction of the human LIMK2 gene expressing alternative transcripts with tissue-specific regulation." in: Biochemical and biophysical research communications, Vol. 229, Issue 2, pp. 582-9, 1997 (PubMed).

Okano, Hiraoka, Otera et al.: "Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs." in: The Journal of biological chemistry, Vol. 270, Issue 52, pp. 31321-30, 1996 (PubMed).

Produktnummer ABIN350731
433,02 €
Zzgl. Versandkosten 20,00 € und MWSt

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