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Pain (3rd Extracellular Loop) Antikörper

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Antigen
Epitop
3rd Extracellular Loop
1
Reaktivität
Fruchtfliege (Drosophila melanogaster)
1
Wirt
Kaninchen
1
Klonalität
Polyklonal
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
1
1
Hersteller
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Immunogen A synthetic peptide from 3d extracellular loop of drosophila Pain conjugated to an immunogenic carrier protein was used as the antigen.
Spezifität Specific for Pain (Transient receptor potential cation channel protein painless).
Reinigung Whole serum
Hintergrund Function: Receptor-activated non-selective cation channel involved in detection of pain sensation due to high temperature. Involved in heat nociception by being activated by noxious temperature of 38 degrees Celsius.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Present in multidendritic neurons, chordotonal neurons, a subset of cells in the central nervous system and a subset of sensory neurons in the antennal-maxillary complex. Not detected in gonads and dorsal vessels (at protein level). Expressed in peripheral neurons that extend multiple branched dendrites beneath the larval epidermis, similar to vertebrate pain receptors.
Developmental stage: Expressed from stage 13 of embryonic development in a small number of cells in the central nervous system and in a subset of neurons of the peripheral nervous system. Such cells may include sensory precursors of multidendritic (md) neurons. At embryonic stage 16, prior to when dendritic process are elaborated, it appears to be expressed in multidendritic neurons in a polarized manner. At stage 17 of development, when the md neurons first initiate dendritogenesis, it is localized to branched projections initiating from clusters of multidendritic neurons. Also known as: Transient receptor potential cation channel protein painless.
Applikationshinweise A dilution of 1 : 300 to 1 : 2000 is recommended.
The optimal dilution should be determined by the end user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Handhabung Avoid freeze and thaw cycles.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Haltbarkeit 12 months
Allgemeine Veröffentlichungen Tracey, Wilson, Laurent et al.: "painless, a Drosophila gene essential for nociception." in: Cell, Vol. 113, Issue 2, pp. 261-73, 2003 (PubMed).

Adams, Celniker, Holt et al.: "The genome sequence of Drosophila melanogaster." in: Science (New York, N.Y.), Vol. 287, Issue 5461, pp. 2185-95, 2000 (PubMed).