Nerve Growth Factor Receptor (NGFR) Antikörper

Antigen: Nerve Growth Factor Receptor (NGFR)

Synonyme: CD271, p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, MGC148470, NGFR, wu:fb38c02, wu:fc10h01, p75, LNGFR, RNNGFRR, nrh1, NRH1b, p75ntr, tnfrsf16, MGC131034

Klonalität: Monoklonal

Wirt: Maus

Applikation: Immunhistochemie (IHC), Immunzytochemie (ICC)

Produktnummer: ABIN350715

Produktbeschreibung

Weitere Bezeichnung: p75NTR (ME20.4, low affinity NGF receptor)

Swiss-Prot: P08138

Immunogen: Human melanoma cell lines

Format: Lyophilized

Isotyp: IgG1  (Passende Sekundärantikörper)

Beschreibung: FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Also known as: Tumor necrosis factor receptor superfamily member 16, P08138, low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, low affinity neurotrophin receptor p75NTR, CD271 antigen, NGFR, TNFRSF16.

Spezifität: Appears to be specific for p75NTR.

Anwendungen

Applikationshinweise: Immunohistochemistry (IHC),Immunocytochemistry (ICC). A concentration of 2-10 µg/ml is recommended. The optimal working concentration should be determined by the end user. This antibody may also be used for immunoabsorptive purification of NGF-receptors. See also the eLab Book at the end of this page.

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Zupan, Osborne, Smith et al.: "Identification, purification, and characterization of truncated forms of the human nerve growth factor receptor." in: The Journal of biological chemistry, Vol. 264, Issue 20, pp. 11714-20, 1989 (PubMed).

Ross, Grob, Bothwell et al.: "Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 21, pp. 6681-5, 1984 (PubMed).

Tremere, Pinaud, Grosche et al.: "Antibody for human p75 LNTR identifies cholinergic basal forebrain of non-primate species." in: Neuroreport, Vol. 11, Issue 10, pp. 2177-83, 2000 (PubMed).