Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2) (4th cytoplasmic domain) Antikörper

Antigen: Purinergic Receptor P2Y, G-Protein Coupled, 2 (P2RY2)

Synonyme: P2U, HP2U, P2U1, P2UR, P2Y2, P2RU1, P2Y2R, MGC20088, MGC40010

Epitope: 4th cytoplasmic domain

Klonalität: Polyklonal

Wirt: Kaninchen

Applikation: Immunhistochemie (IHC)

Produktnummer: ABIN350706

Produktbeschreibung

Weitere Bezeichnung: P2Y2 (P2RY2) (4th (cytoplasmic domain))

Swiss-Prot: P35383

Immunogen: A synthetic peptide from the 4th cytoplasmic domain of mouse P2Y2 (P2RY2, P2U purinoceptor 1, Purinergic receptor, ATP receptor) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 96% identity with rat sequence and 92% with human's.

Format: Lyophilized

Beschreibung: FUNCTION: Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S > 2-methylthio-ATP = ADP. Subcellular location: Membrane; Multi-pass membrane protein. Tissue specificity: Spleen, testis, kidney, liver, lung, heart and brain. Also known as: P2Y purinoceptor 2, P2U purinoceptor 1, P2U1, P2RY2, Purinergic receptor, ATP receptor.

Spezifität: Appears to be specific for P2RY2.

Anwendungen

Applikationshinweise: IHC. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Lustig, Shiau, Brake et al.: "Expression cloning of an ATP receptor from mouse neuroblastoma cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 11, pp. 5113-7, 1993 (PubMed).

Enomoto, Furuya, Moore et al.: "Expression cloning and signal transduction pathway of P2U receptor in mammary tumor cells." in: Biological signals, Vol. 5, Issue 1, pp. 9-21, 1996 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).