Greenred-Sensitive Opsin 1 (OPSG/OPSR) Antikörper

Antigen: Greenred-Sensitive Opsin 1 (OPSG/OPSR)

Synonyme: RH2-2, grops1, grops2, wu:fk57c11, si:zc263a23.4, RH2-3, si:zc263a23.3

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN350679

Produktbeschreibung

Weitere Bezeichnung: OPSG and OPSR (greenred-sensitive opsin opsin 1, M opsin)

Swiss-Prot: P04001

Immunogen: A synthetic peptide from human OPSG and OPSR (green & red-sensitive opsin, OPN1MW, OPN1LW, GCP, RCP, CBBM, opsin 1) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Beschreibung: FUNCTION: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. BIOPHYSICOCHEMICAL PROPERTIES: Absorption:       Abs(max)=530 nm; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: The three color pigments are found in the cone photoreceptor cells. PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. DISEASE: Defects in OPN1MW are the cause of partial colorblindness deutan series (CBD); also called deuteranopia. Also known as: Green-sensitive opsin, green cone photoreceptor pigment, OPN1MW, OPN1LW, GCP, RCP, CBBM, OPN1MW1, opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan), red-sensitive opsin, red cone photoreceptor pigment, M opsin.

Spezifität: Appears to be specific for OPSG and OPSR.

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Winderickx, Sanocki, Lindsey et al.: "Defective colour vision associated with a missense mutation in the human green visual pigment gene." in: Nature genetics, Vol. 1, Issue 4, pp. 251-6, 1993 (PubMed).

Nathans, Thomas, Hogness: "Molecular genetics of human color vision: the genes encoding blue, green, and red pigments." in: Science (New York, N.Y.), Vol. 232, Issue 4747, pp. 193-202, 1986 (PubMed).

Applebury, Hargrave: "Molecular biology of the visual pigments." in: Vision research, Vol. 26, Issue 12, pp. 1881-95, 1987 (PubMed).