Multiple PDZ Domain Protein (MPDZ) (internal) Antikörper

Antigen: Multiple PDZ Domain Protein (MPDZ)

Synonyme: MUPP1, FLJ25909, FLJ34626, FLJ90240, DKFZp781P216, AI225843, B930003D11Rik

Epitope: internal

Klonalität: Polyklonal

Wirt: Kaninchen

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN350501

Produktbeschreibung

Weitere Bezeichnung: Multiple PDZ domain protein (MPDZ, MUPP1) (internal region)

Swiss-Prot: O75970

Immunogen: A synthetic peptide from internal part of human Multiple PDZ domain protein (MPDZ, MUPP1) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Beschreibung: Function: Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell junction, synapse. Cell junction, tight junction. Cell junction, synapse. Cell junction, synapse, synaptosome. Note:  Associated with membranes. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells. In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR. Tissue specificity: Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Also known as: MPDZ, MUPP1, Multi PDZ domain protein 1, Multi-PDZ domain protein 1.

Spezifität: Appears to be specific for MPDZ.

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Ullmer, Schmuck, Figge et al.: "Cloning and characterization of MUPP1, a novel PDZ domain protein." in: FEBS letters, Vol. 424, Issue 1-2, pp. 63-8, 1998 (PubMed).

Lee, Glaunsinger, Mantovani et al.: "Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins." in: Journal of virology, Vol. 74, Issue 20, pp. 9680-93, 2000 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Humphray, Oliver, Hunt et al.: "DNA sequence and analysis of human chromosome 9." in: Nature, Vol. 429, Issue 6990, pp. 369-74, 2004 (PubMed).

Dephoure, Zhou, Villuen et al.: "A quantitative atlas of mitotic phosphorylation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 31, pp. 10762-7, 2008 (PubMed).