Olfactory Marker Protein (OMP) Antikörper

Antigen: Olfactory Marker Protein (OMP)

Synonyme: zgc:101697, xomp1, xomp2, omp2-A, omp, MGC75776, OMP

Klonalität: Monoklonal

Wirt: Maus

Reaktivität: Ratte (Rattus), Maus

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN350470

Produktbeschreibung

Weitere Bezeichnung: OMP (Olfactory Marker Protein)

Swiss-Prot: P08523

Immunogen: A synthetic peptide from rat Olfactory Marker Protein (OMP) conjugated to an immunogenic carrier protein has been used as the immunogen. The peptide is homologous in mouse.

Format: Lyophilized

Beschreibung: Olfactory marker protein (OMP) is an abundant, 19-kDa, cytosolic protein that is almost exclusively expressed in mature, functioning,olfactory neurons but not in the neural precursor basal cells. The OMP gene structure and protein sequence are highly conserved between mouse, rat and human. Its tissue-specific expression in the receptor cells together with the results of the mouse knockout studies show that OMP represents a novel modulatory component of the odor detection/signal transduction cascade. FUNCTION: May act as a modulator of theolfactory signal-transduction cascade. SUBUNIT: Interacts with BEX1 and BEX2. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Uniquely associated with matureolfactory receptor neurons. SIMILARITY: Belongs to theolfactory marker protein family.<||a href="http://www.enzim.hu/hmmtop1.1/server/submit.html" /> Also known as:olfactory neuronal-specific protein.

Spezifität: Highly specific for mature olfactory neurons (including axon and terminals).

Anwendungen

Applikationshinweise: IHC, WB. Use at a dilution of 1 : 200 to 1 : 2000. The optimal dilution should be determined by the end user. For IHC, Zamboni's or 4% PFA fixatives are recommended.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Margolis: "Olfactory marker protein (OMP)." in: Scandinavian journal of immunology. Supplement, Vol. 9, pp. 181-99, 1983 (PubMed).

Walters, Grillo, Oestreicher et al.: "LacZ and OMP are co-expressed during ontogeny and regeneration in olfactory receptor neurons of OMP promoter-lacZ transgenic mice." in: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, Vol. 14, Issue 7-8, pp. 813-22, 1997 (PubMed).

Baldisseri, Margolis, Weber et al.: "Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction." in: Journal of molecular biology, Vol. 319, Issue 3, pp. 823-37, 2002 (PubMed).

Moriya-Ito, Osada, Ishimatsu et al.: "Maturation of vomeronasal receptor neurons in vitro by coculture with accessory olfactory bulb neurons." in: Chemical senses, Vol. 30, Issue 2, pp. 111-9, 2005 (PubMed).