KCNJ2 Antikörper (Cytoplasmic Domain)

Produktnummer ABIN350394

Produktdetails anti-KCNJ2 Antikörper

Target: KCNJ2 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 2 (KCNJ2))

Bindungsspezifität: Cytoplasmic Domain

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KCNJ2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Specific for KCNJ2.

Kreuzreaktivität: Human, Maus, Ratte

Kreuzreaktivität (Details): Other species not yet tested.

Aufreinigung: IgG

Immunogen: A synthetic peptide from the cytoplasmic domain of mouse KCNJ2 (HIRK1, IRK1, Kir2.1) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and human.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu KCNJ2

Target: KCNJ2 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 2 (KCNJ2))

Andere Bezeichnung: KCNJ2 (KCNJ2 Produkte)

Synonyme: KCNJ2 antikoerper, ATFB9 antikoerper, HHBIRK1 antikoerper, HHIRK1 antikoerper, IRK1 antikoerper, KIR2.1 antikoerper, LQT7 antikoerper, SQT3 antikoerper, Kir2.1 antikoerper, Kcnf1 antikoerper, IRK-1 antikoerper, potassium voltage-gated channel subfamily J member 2 antikoerper, potassium inwardly-rectifying channel, subfamily J, member 2 antikoerper, KCNJ2 antikoerper, Kcnj2 antikoerper

Hintergrund: FUNCTION: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium. Tissue specificity: Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain. Subcellular location: Membrane, Multi-pass membrane protein. Involvement in disease: Defects in KCNJ2 are the cause of long QT syndrome type 7 (LQT7), also called Andersen syndrome or Andersen cardiodysrhythmic periodic paralysis. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. LQT7 manifests itself as a clinical triad consisting of potassium-sensitive periodic paralysis, ventricular ectopy and dysmorphic features. Defects in KCNJ2 are the cause of short QT syndrome type 3 (SQT3). Short QT syndromes are heart disorders characterized by idiopathic persistently and uniformly short QT interval on ECG in the absence of structural heart disease in affected individuals. They cause syncope and sudden death. SQT3 has a unique ECG phenotype characterized by asymmetrical T waves.,Inward Rectifier,Inward rectifier potassium channel 2, Potassium channel, inwardly rectifying subfamily J member 2, Inward rectifier K(+) channel Kir2.1, Cardiac inward rectifier potassium channel, IRK1

UniProt: P35561