Potassium Inwardly-Rectifying Channel, Subfamily J, Member 15 (KCNJ15) (cytoplasmic domain) Antikörper

Antigen: Potassium Inwardly-Rectifying Channel, Subfamily J, Member 15 (KCNJ15)

Synonyme: IRKK, KIR1.3, KIR4.2, MGC13584, Kir4.2, AI182284, AI267127, 4930414N08Rik, kcnj1, MGC68935, KCNJ15, MGC160064

Epitope: cytoplasmic domain

Klonalität: Polyklonal

Wirt: Kaninchen

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN350392

Produktbeschreibung

Weitere Bezeichnung: KCNJ15 (KCNJ14, Kir4.2) (cytoplasmic domain)

Swiss-Prot: Q99712

Immunogen: A synthetic peptide from the cytoplasmic domain of human KCNJ15 (KCNJ14, Kir4.2) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Beschreibung: FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Subcellular location: Membrane, Multi-pass membrane protein. Also known as: ATP-sensitive inward rectifier potassium channel 15, Potassium channel, inwardly rectifying subfamily J member 15, Inward rectifier K(+) channel Kir4.2, KCNJ14, Kir4.2.

Spezifität: Appears to be specific for KCNJ15.

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Shuck, Piser, Bock et al.: "Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3)." in: The Journal of biological chemistry, Vol. 272, Issue 1, pp. 586-93, 1997 (PubMed).

Gosset, Ghezala, Korn et al.: "A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1)." in: Genomics, Vol. 44, Issue 2, pp. 237-41, 1997 (PubMed).

Kurschner, Mermelstein, Holden et al.: "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins." in: Molecular and cellular neurosciences, Vol. 11, Issue 3, pp. 161-72, 1998 (PubMed).

Sjoeblom, Jones, Wood et al.: "The consensus coding sequences of human breast and colorectal cancers." in: Science (New York, N.Y.), Vol. 314, Issue 5797, pp. 268-74, 2006 (PubMed).