Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4) (C-Term) Antikörper

Antigen: Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4)

Synonyme: HCN4, hcn4

Epitope: C-Term

Klonalität: Polyklonal

Wirt: Kaninchen

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN350363

Produktbeschreibung

Weitere Bezeichnung: HCN4 (c-terminal region)

Swiss-Prot: Q9JKA7

Immunogen: A synthetic peptide from c-terminal region of rat HCN4 conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Beschreibung: FUNCTION: Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli. SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Highly expressed in pyramidal and granule layer of the hippocampus, in thalamus anterior nucleus, in the supraoptic nucleus in hypothalamus, in cerebellum, and in trapezoid nuclei and superior olivary complex in the auditory system. Detected in a subset of elongated cells in taste buds. Also known as: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4.

Spezifität: Appears to be specific for HCN4.

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Shi, Wymore, Yu et al.: "Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues." in: Circulation research, Vol. 85, Issue 1, pp. e1-6, 1999 (PubMed).

Monteggia, Eisch, Tang et al.: "Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain." in: Brain research. Molecular brain research, Vol. 81, Issue 1-2, pp. 129-39, 2000 (PubMed).

Stevens, Seifert, Bufe et al.: "Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli." in: Nature, Vol. 413, Issue 6856, pp. 631-5, 2001 (PubMed).