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GABARAP-L2 (AA 10-50) Antikörper

Reaktivität: Human, Maus, Ratte IHC, WB Wirt: Schaf Polyclonal unconjugated
Produktnummer ABIN350325
  • Target
    GABARAP-L2
    Bindungsspezifität
    AA 10-50
    Reaktivität
    Human, Maus, Ratte
    Wirt
    Schaf
    Klonalität
    Polyklonal
    Applikation
    Immunohistochemistry (IHC), Western Blotting (WB)
    Spezifität
    Specific for GABARAPL2.
    Immunogen
    A synthetic peptide from aa region 10-50 of human GABA(A) conjugated to an immunogenic carrier protein has been used as the antigen. The antigen is homologous in rat and mouse.
    Isotyp
    IgG
  • Applikationshinweise
    Use at a concentration of 10-50 µg/ml.
    The optimal working concentration should be determined by the end user.
    Not yet tested in other applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
    Handhabung
    Avoid freeze and thaw cycles.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Haltbarkeit
    12 months
  • Target
    GABARAP-L2
    Hintergrund
    Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly.autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels ofautophagy have been described in some malignant tumors, and a role forautophagy in controlling the unregulated cell growth linked to cancer has been proposed. Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association withGOSR1.
    Subcellular location: Golgi apparatus.
    Tissue specificity: Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine. Also known as: FLC3A, GABARAPL2, ATG8, GEF2, GEF-2, GATE16, GATE-16, Gamma-aminobutyric acid receptor-associated protein-like 2, GABA(A) receptor-associated protein-like 2, Ganglioside expression factor 2, General protein transport factor p16, MAP1 light chain 3-related protein.
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