SLC1A1 Antikörper (Extracellular Domain)

Produktnummer ABIN350316

Produktdetails anti-SLC1A1 Antikörper

Target: SLC1A1 (Solute Carrier Family 1 (Neuronal/epithelial High Affinity Glutamate Transporter, System Xag), Member 1 (SLC1A1))

Bindungsspezifität: AA 150-200, Extracellular Domain

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC1A1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Specific for EAAT3.

Kreuzreaktivität: Human, Maus, Ratte

Kreuzreaktivität (Details): Other species not yet tested.

Aufreinigung: IgG

Immunogen: A synthetic peptide from extracellular domain of human EAAT3 (AA 150-200) conjugated to an immunogenic carrier protein was used as the antigen. The peptide shares 96% identity with rat and mouse sequence.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu SLC1A1

Target: SLC1A1 (Solute Carrier Family 1 (Neuronal/epithelial High Affinity Glutamate Transporter, System Xag), Member 1 (SLC1A1))

Andere Bezeichnung: SLC1A1 (SLC1A1 Produkte)

Synonyme: GB16911 antikoerper, EAAT3 antikoerper, SLC1A2a antikoerper, zgc:91959 antikoerper, EAAC1 antikoerper, SCZD18 antikoerper, D130048G10Rik antikoerper, EAAC2 antikoerper, MEAAC1 antikoerper, Eaac1 antikoerper, Eaat3 antikoerper, REAAC1 antikoerper, excitatory amino acid transporter 3 antikoerper, solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 antikoerper, solute carrier family 1 member 1 antikoerper, LOC412382 antikoerper, slc1a1 antikoerper, SLC1A1 antikoerper, CpipJ_CPIJ000674 antikoerper, CpipJ_CPIJ001134 antikoerper, Slc1a1 antikoerper

Hintergrund: FUNCTION: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5. Defects in SLC1A1 may be a cause of dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. This is as defect in renal and probably intestinal transport of glutamic and aspartic acids and is associated with moderate hyperprolinemia. SUBCELLULAR LOCATION: Membrane, Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers).,SLC1 Family,Sodium-dependent glutamate/aspartate transporter 3, Excitatory amino-acid carrier 1, Neuronal and epithelial glutamate transporter, Solute carrier family 1 member 1, EAAC1, EAAT3, SLC1A1

UniProt: P43005

Pathways: Dicarboxylic Acid Transport