CACNB4 Antikörper (C-Term)

Produktnummer ABIN350161

Produktdetails anti-CACNB4 Antikörper

Target: CACNB4 (Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CACNB4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Specific for CACNB4.

Kreuzreaktivität: Human, Maus, Ratte

Kreuzreaktivität (Details): Other species not yet tested.

Aufreinigung: IgG

Immunogen: A synthetic peptide from the c-terminal region of human CACNB4 (CACB4, Voltage dependent L-type calcium channel subunit beta-4) conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in many species including mouse and rat.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu CACNB4

Target: CACNB4 (Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4))

Andere Bezeichnung: CACNB4 (CACNB4 Produkte)

Synonyme: CAB4 antikoerper, CACNLB4 antikoerper, EA5 antikoerper, EIG9 antikoerper, EJM antikoerper, EJM4 antikoerper, EJM6 antikoerper, 3110038O15Rik antikoerper, Cchb4 antikoerper, lethargic antikoerper, lh antikoerper, CACNB4 antikoerper, cacnb4.2 antikoerper, calcium voltage-gated channel auxiliary subunit beta 4 antikoerper, calcium channel, voltage-dependent, beta 4 subunit antikoerper, calcium channel, voltage-dependent, beta 4a subunit antikoerper, CACNB4 antikoerper, Cacnb4 antikoerper, cacnb4.1 antikoerper, cacnb4 antikoerper, cacnb4a antikoerper

Hintergrund: FUNCTION: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB4 are associated with susceptibility to idiopathic generalized epilepsy (IGE). IGE is characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Defects in CACNB4 are a cause of juvenile myoclonic epilepsy (EJM). EJM is a subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Tissue specificity: Expressed predominantly in the cerebellum and kidney.,Beta Subunit,CACB4, Voltage-dependent L-type calcium channel subunit beta-4, Calcium channel voltage-dependent subunit beta 4

UniProt: O00305

Pathways: cAMP Metabolic Process, Skeletal Muscle Fiber Development