CACNA1I Antikörper (Cytoplasmic Domain)

Produktnummer ABIN350147

Produktdetails anti-CACNA1I Antikörper

Target: CACNA1I (Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I))

Bindungsspezifität: Cytoplasmic Domain

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CACNA1I Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Spezifität: Specific for CACNA1I.

Kreuzreaktivität: Human, Maus, Ratte

Kreuzreaktivität (Details): Other species not yet tested.

Aufreinigung: IgG

Immunogen: A synthetic peptide from a cytoplasmic domain of human CACNA1I conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC, WB. A concentration of 10-50 μg,ml is recommended. The optimal concentration should be determined by the end user. Not tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu CACNA1I

Target: CACNA1I (Calcium Channel, Voltage Dependent, T Type, alpha 1I Subunit (CACNA1I))

Andere Bezeichnung: CACNA1I (CACNA1I Produkte)

Synonyme: CACNA1L antikoerper, Ca(V)3.3 antikoerper, Cav3.3 antikoerper, ca(v)3.3 antikoerper, si:ch211-51h13.1 antikoerper, Ca(v)3.3 antikoerper, calcium voltage-gated channel subunit alpha1 I antikoerper, voltage-dependent T-type calcium channel subunit alpha-1I antikoerper, calcium channel, voltage-dependent, alpha 1I subunit antikoerper, calcium channel, voltage-dependent, T type, alpha 1I subunit antikoerper, CACNA1I antikoerper, LOC100555412 antikoerper, Cacna1i antikoerper, cacna1i antikoerper

Hintergrund: Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H. Subcellular location: Membrane, Multi-pass membrane protein. Tissue specificity: Brain specific,Alpha Subunit,Voltage-dependent T-type calcium channel subunit alpha-1I, Voltage-gated calcium channel subunit alpha Cav3.3

UniProt: Q9P0X4