Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) Antikörper

Antigen: Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)

Synonyme: Bex, BEX3, NADE, HGR74, DXS6984E, NGFRAP1

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN350124

Produktbeschreibung

Weitere Bezeichnung: Brain-expressed X-linked protein 3 (BEX3, NGFRAP1, NADE)

Swiss-Prot: Q00994

Immunogen: A synthetic peptide from human Brain-expressed X-linked protein 3 (BEX3, NGFRAP1, NADE) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Beschreibung: FUNCTION: May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. May play an important role in the pathogenesis of neurogenetic diseases. SUBUNIT: Self-associates. Interacts with 14-3-3 epsilon. Interacts with DIABLO/SMAC. Binds to the DEATH domain of p75NTR/NGFR. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria. TISSUE SPECIFICITY: Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver. Also known as: Protein BEX3, NGFRAP1, p75NTR-associated cell death executor, Nerve growth factor receptor-associated protein 1 (TNFRSF16) associated protein 1, Ovarian granulosa cell 13.0 kDa protein HGR74, BEX3, DXS6984E, NADE, Bex, HGR74, DXS6984E.

Spezifität: Appears to be specific for BEX3.

Anwendungen

Applikationshinweise: IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Rapp, Freudenstein, Klaudiny et al.: "Characterization of three abundant mRNAs from human ovarian granulosa cells." in: DNA and cell biology, Vol. 9, Issue 7, pp. 479-85, 1990 (PubMed).

Mukai, Hachiya, Shoji-Hoshino et al.: "NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR." in: The Journal of biological chemistry, Vol. 275, Issue 23, pp. 17566-70, 2000 (PubMed).

Ross, Grafham, Coffey et al.: "The DNA sequence of the human X chromosome." in: Nature, Vol. 434, Issue 7031, pp. 325-37, 2005 (PubMed).

Alvarez, Zhou, Witta et al.: "Characterization of the Bex gene family in humans, mice, and rats." in: Gene, Vol. 357, Issue 1, pp. 18-28, 2005 (PubMed).