Autophagy Related Protein 16-1 (ATG16L1) Antikörper

Antigen: Autophagy Related Protein 16-1 (ATG16L1)

Synonyme: IBD10, WDR30, APG16L, ATG16L, FLJ00045, FLJ10035, FLJ10828, FLJ22677, Apg16l, Atg16l, AI035639, AI225866, 1500009K01Rik, zgc:110147, DKFZp469O1320

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Maus

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN350100

Produktbeschreibung

Weitere Bezeichnung: autophagy-related protein 16-1 (Atg16l1, APG16L) isoforms 1, 2, 3, 4, 5

Swiss-Prot: Q8C0J2

Immunogen: A synthetic peptide as a part of mouse autophagy-related protein 16-1 (Atg16l1, APG16L) isoforms 1, 2, 3, 4, 5 conjugated to an immunogenic carrier protein has been used as the immunogen.

Format: Lyophilized

Beschreibung: FUNCTION: Plays an essential role inautophagy. SUBUNIT: Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). SUBCELLULAR LOCATION: Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note: Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. DISEASE: Genetic variations in ATG16L1 are associated with susceptibility to inflammatory bowel disease type 10 (IBD10). IBD is characterized by a chronic relapsing intestinal inflammation. IBD is subdivided into Crohn disease (CD) and ulcerative colitis phenotypes. IBD10 individuals show the phenotype characteristic to CD. It may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. CD is commonly classified as autoimmune disease. Also known as: ATG16L1, APG16L, IBD10, WDR30, APG16L, ATG16L, FLJ00045, FLJ10035, FLJ10828, FLJ22677.

Spezifität: Appears to be specific for ATG16L1.

Anwendungen

Applikationshinweise: IHC, WB. Use at a dilution of 1 : 100 to 1 : 2000. The optimal dilution should be determined by the end user.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Forschungsgebiet: Autophagie

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Mizushima, Kuma, Kobayashi et al.: "Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate." in: Journal of cell science, Vol. 116, Issue Pt 9, pp. 1679-88, 2003 (PubMed).

Okazaki, Kikuno, Ohara et al.: "Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 11, Issue 2, pp. 127-35, 2004 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Villuen, Beausoleil, Gerber et al.: "Large-scale phosphorylation analysis of mouse liver." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 5, pp. 1488-93, 2007 (PubMed).