Alstrom Syndrome 1 (ALMS1) (C-Term) Antikörper

Antigen: Alstrom Syndrome 1 (ALMS1)

Synonyme: ALSS, KIAA0328, DKFZp686A118, DKFZp686D1828, bbb, ALMS1

Epitope: C-Term

Klonalität: Polyklonal

Wirt: Kaninchen

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN350040

Produktbeschreibung

Weitere Bezeichnung: Alstrom syndrome protein 1 homolog (ALMS1) (c-terminal region)

Swiss-Prot: P60880

Immunogen: A synthetic peptide from C-terminal part of mouse Alstrom syndrome protein 1 homolog (ALMS1) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Beschreibung: FUNCTION: Possible role in intracellular trafficking. SUBCELLULAR LOCATION: Cytoplasm. Centrosome. Cell projection, cilium basal body. Note: Associated with centrosomes and basal body at the base of primary cilia. During mitosis localizes to both spindle poles. TISSUE SPECIFICITY: Ubiquitously expressed. DEVELOPMENTAL STAGE: Expressed at E7.5. At E8.0 expression is found in mesodermal- and ectodermal-derived layers. At E10.5 mainly detected in midbrain, hindbrain, forelimb and hindlimb. Also expressed at E15.5 and E18.5. MISCELLANEOUS: Mice lacking Alms1 display obesity, hypogonadism, hyperinsulinemia, retinal dysfunction and hearing loss. Also known as: ALMS1.

Spezifität: Appears to be specific for ALMS1.

Anwendungen

Applikationshinweise: IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

Reinheit: whole serum

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Collin, Marshall, Ikeda et al.: "Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory degeneration in Alström syndrome." in: Nature genetics, Vol. 31, Issue 1, pp. 74-8, 2002 (PubMed).

Okazaki, F-Kikuno, Ohara et al.: "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 11, Issue 3, pp. 205-18, 2004 (PubMed).

Collin, Cyr, Bronson et al.: "Alms1-disrupted mice recapitulate human Alström syndrome." in: Human molecular genetics, Vol. 14, Issue 16, pp. 2323-33, 2005 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Dai, Jin, Sheng et al.: "Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." in: Journal of proteome research, Vol. 6, Issue 1, pp. 250-62, 2007 (PubMed).