A Kinase (PRKA) Anchor Protein (Yotiao) 9 (AKAP9) Antikörper (AP)

Antigen: A Kinase (PRKA) Anchor Protein (Yotiao) 9 (AKAP9)

Synonyme: PRKA9, CG-NAP, YOTIAO, AKAP350, AKAP450, HYPERION, KIAA0803, MU-RMS-40.16A, AKAP-9, C79026, AW545847, mKIAA0803, 5730481H23Rik, Gisp, Yotiao, AKAP9, wu:fj02h02, prka9, yotiao, akap350, akap450, hyperion, AKAP18, Akap7, Akap15, Akap18, AKAP18d, MGC112559, AKAP15, AI662165, BB170514, 6430401D08, akap15, akap18, MGC83920, AKAP7, MGC139521

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus)

Konjugat: Alkaline Phosphatase (AP)

Applikation: Western Blot (WB), ELISA, Immunpräzipitation (IP)

Produktnummer: ABIN349075

Produktbeschreibung

Weitere Bezeichnung: YOTIAO/AKAP9

Immunogen: Synthetic peptide derived from the C-terminal region of the human Yotiao protein.

Isotyp: IgG

Beschreibung: Yotiao is a novel cytoskeletal protein specifically concentrated in the neuromuscular junction and neuronal synapes that interacts with specific splice variants of NMDA Receptor Subunit NR1 in a C1 exon cassette-dependent manner.1 Yotiao hasalso been shown to physically attach theI protein phosphatase (PP1) and the adenosine 3',5'-mono-phosphate (cAMP)- dependent protein kinase (PKA) holoenzyme to NMDA receptors to regulate channel activity. NMDAreceptors are involved with many important functions and dysfunctions of the nervous system, including synapse formation, synaptic plasticity, and excitotoxicity. Yotiao research may lead to a clearer understanding of these neural processes by explaining how NMDA receptors are targeted to particular synapses, how this localization is regulated during development and synaptic activity, is transduced into intracellular signals responsible for particular neuronal responses. 1 Human tissue distribution studies with yotiao mRNA revealed that yotiao is abundantly present in skeletal muscle andpancreas, with lower expression in heart, placenta, and brain. Yotiao mRNA was undetectable in lung,liver, and kidney .1

Spezifität: Reactivity has been confirmed with AsPC-1 (human pancreatic adenocarcinoma) cell lysates and rat brain tissue homogenates, in addition to fetal mouse brain homogenates.This antibody reacts with the Yotiao protein. On Western blots of fetal mouse brain, a clear single band at ~230 kDa is observed. On Western blots of AsPC-1 lysates and rat brain homogenates, multiple bands at other molecular weights have also been observed.

Synonyme: PRKA9, CG-NAP, YOTIAO, AKAP350, AKAP450, HYPERION, KIAA0803, MU-RMS-40.16A, AKAP-9, C79026, AW545847, mKIAA0803, 5730481H23Rik, Gisp, Yotiao, AKAP9, wu:fj02h02, prka9, yotiao, akap350, akap450, hyperion, AKAP18, Akap7, Akap15, Akap18, AKAP18d, MGC112559, AKAP15, AI662165, BB170514, 6430401D08, akap15, akap18, MGC83920, AKAP7, MGC139521

Anwendungen

Applikationshinweise: Working concentrations for specific applications should be determined by the investigator. Appropriate concentrations will be affected by several factors, including secondary antibody affinity, antigen concentration, sensitivity of detection method, temperature and length of incubations, etc. The suitability of this antibody for applications other than those listed below has not been determined. The following concentration ranges are recommended starting points for this product. ELISA: 0.1-1.0 ug/ml Western Blotting: 1-3 ug/ml

Buffer: This polyclonal antibody is supplied as a 400 ul aliquot at a concentration of 0.25 mg/ml in phosphate buffered saline (pH7.4) containing 0.05% sodium azide. The antibody is epitope-affinity-purified from rabbit antiserum.

Beschränkungen: Nur für Forschungszwecke einsetzbar