JAK1 Pan Antikörper

Antigen: JAK1 Pan

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus)

Applikation: Western Blot (WB)

Produktnummer: ABIN348474

Produktbeschreibung

Immunogen: The antibody was produced using a synthetic peptide derived from an internal region of human JAK1.

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Janus Kinase 1 (JAK1) is a 130 kDa tyrosine kinase involved in cytoplasmic signal transduction. Ligand binding to a variety of cell surface receptors (e.g., cytokine, growth factor, GPCRs) leads to an association of those receptors with JAK proteins, which are then activated via phosphorylation of tyrosine residues in the kinase activation loop. Activated JAK proteins phosphorylate and activate STAT (signal transducers and activators of transcription) proteins, which then dimerize and translocate to the nucleus. Once in the nucleus, STAT proteins bind to DNA and modify the transcription of various genes, which can lead to various responses such as cell proliferation, cell survival and differentiation. This antibody is useful to determine total levels of JAK1 protein.

Spezifität: Recognizes JAK1 in human, mouse and rat samples.

Anwendungen

Applikationshinweise: The antibody can be used for Western blot analysis (1:1,000). However, the optimal conditions should be determined individually.

Buffer: Supplied as 100 ul rabbit polyclonal immunoglobulin in Dulbecco's phosphate buffered saline (without Mg 2+ and Ca 2+ ), pH 7.3, 50% glycerol, 1.0 mg/ml BSA (IgG and protease free), and 0.05% sodium azide. PREPARATION: Purified from rabbit serum by epitope

Beschränkungen: Nur für Forschungszwecke einsetzbar