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	+49 (0)241 95 163 153
	+49 (0)241 95 163 155

Protein tyrosine Phosphatase, Receptor Type, C (PTPRC) Antikörper (PE)

Antigen	Protein tyrosine Phosphatase, Receptor Type, C (PTPRC)
Synonyme	LCA, LY5, B220, CD45, T200, CD45R, GP180, Lca, RT7, L-CA, PTPRC, si:dkeyp-47c5.1
Klonalität	Monoklonal (EM-05)
Wirt	Alternativen Ratte Maus (523), Ratte (395), Kaninchen (23), Huhn (1)
Reaktivität	Alternativen Maus Human (436), Maus (369), Ratte (Rattus) (92), Katze (52), Hund (36), Huhn (34), Rind (Kuh) (20), Schaf (17), Schwein (12), Affe (9), Vogel (5), Primate (4), Ziege (3), Meerschweinchen (3), Kaninchen (2), Schimpanse (1)
Konjugat	Alternativen PE FITC (136), PE (99), Biotin (90), APC (47), PE,Cy5 (23), PE,Cy7 (16), PerCP,Cy5.5 (14), RPE (14), Alexa Fluor 488 (12), Alexa Fluor 647 (12), Alexa Fluor 700 (11), Cy5 (11), Pacific Blue (9), PerCP (9), APC,Cy7 (8), SPRD (8), Cy5,PE (4), Cy5.5,PE (4), EFluor 450 (4), APC-eFluor 780 (3), Cy7,PE (3), PE,Cy5.5 (3), Cy5.5 (2), DY647 (2), PE,DY647 (2), RPE,Cy5 (2), Alexa Fluor 350 (1), Alexa Fluor 555 (1), PE,DY590 (1), PE,Texas Red (TR) (1), PE-Dyomics 590 (1), PE-Dyomics 647 (1)
Applikation	Alternativen Durchflusszytometrie (FACS) Durchflusszytometrie (FACS) (839), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (240), Immunpräzipitation (IP) (186), Immunhistochemie (Paraffinschnitte) (IHC (p)) (150), Western Blot (WB) (72), Immunfluoreszenz (IF) (41), Immunhistochemie (IHC) (37), ELISA (16), Immunzytochemie (ICC) (11), Enzyme Immunoassay (EIA) (10), Funktionale Studien (Func) (8), Zytotoxizitätstest (CyTox) (4), Radioimmunoassay (RIA) (2), Aktivierung (Act) (1), Dot Blot (Dot) (1), To be determined by user (TBD) (1)

Produktnummer	ABIN343727
Menge	0.1 mg (0.5 mg/ml)
Preis	170,00 € Zzgl. Versandkosten €20,00 und MWSt
Lieferung nach
Verfügbarkeit	Lieferung in 3 bis 5 Werktagen

Produktbeschreibung
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Weitere Bezeichnung	CD45
Immunogen	Murine peripheral blood leukocytes
Isotyp	IgG
Klon	EM-05
Beschreibung	CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphataseubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10%of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocytedevelopment and antigen signaling, serving as an important regulator of Src-family kinases.CD45 protein exists as multiple isoforms as a result of alternative splicing, these isoformsdiffer in their extracellular domains, whereas they share identical transmembrane andcytoplasmic domains. These isoforms differ in their ability to translocate into theglycosphingolipid-enriched membrane domains and their expression depends on cell typeand physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 isimportant in promoting cell survival by modulating integrin-mediated signal transductionpathway and is also involved in DNA fragmentation during apoptosis.
Spezifität	The antibody EM-05 reacts with mouse CD45 antigen (Leukocyte Common Antigen), asingle chain type I transmembrane protein expressed at high level on cells of hematopoieticorigin, except erythrocytes and platelets.

Anwendungen
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Applikationshinweise	The reagent is designed for Flow Cytometry analysis. Suggested working concentration is 4 µg/ml. Indicated dilution is recommended startingpoint for use of this product. Working concentrations should be determined by the investigator.
Konzentration	0.5 mg/ml
Buffer	The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azideand 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
Lagerung	Store in the dark at 2-8 o C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.Short-term exposure to room temperature should not affect the quality of the reagent.However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user.
Forschungsgebiet	Immunologie, Adaptive Immunität, Hämopoetische Vorläufer, Glia Marker, CD Antigene, Oberflächenrezeptoren der Immunzellen
Beschränkungen	Nur für Forschungszwecke einsetzbar

Bilder
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Surface staining of C57BL/6 cells and CD45 knock-out cells with anti-CD45 antibodies EM-05 and ALI-4A2.

Alternativen
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Alternativen zu Antigen "Protein tyrosine Phosphatase, Receptor Type, C (PTPRC)", Typ "Antikörper" finden

Wirte	Maus (523), Ratte (395), Kaninchen (23), Huhn (1)
Reaktivitäten	Human (436), Maus (369), Ratte (Rattus) (92), Katze (52), Hund (36), Huhn (34), Rind (Kuh) (20), Schaf (17), Schwein (12), Affe (9), Vogel (5), Primate (4), Ziege (3), Meerschweinchen (3), Kaninchen (2), Schimpanse (1)
Applikationen	Durchflusszytometrie (FACS) (839), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (240), Immunpräzipitation (IP) (186), Immunhistochemie (Paraffinschnitte) (IHC (p)) (150), Western Blot (WB) (72), Immunfluoreszenz (IF) (41), Immunhistochemie (IHC) (37), ELISA (16), Immunzytochemie (ICC) (11), Enzyme Immunoassay (EIA) (10), Funktionale Studien (Func) (8), Zytotoxizitätstest (CyTox) (4), Radioimmunoassay (RIA) (2), Aktivierung (Act) (1), Dot Blot (Dot) (1), To be determined by user (TBD) (1)
Konjugate	FITC (136), PE (99), Biotin (90), APC (47), PE,Cy5 (23), PE,Cy7 (16), PerCP,Cy5.5 (14), RPE (14), Alexa Fluor 488 (12), Alexa Fluor 647 (12), Alexa Fluor 700 (11), Cy5 (11), Pacific Blue (9), PerCP (9), APC,Cy7 (8), SPRD (8), Cy5,PE (4), Cy5.5,PE (4), EFluor 450 (4), APC-eFluor 780 (3), Cy7,PE (3), PE,Cy5.5 (3), Cy5.5 (2), DY647 (2), PE,DY647 (2), RPE,Cy5 (2), Alexa Fluor 350 (1), Alexa Fluor 555 (1), PE,DY590 (1), PE,Texas Red (TR) (1), PE-Dyomics 590 (1), PE-Dyomics 647 (1)
Epitope	C-Term (3)